CBP/beta-catenin Antagonist PRI-724

Known as: PRI-724 
A potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling… (More)

Topic mentions per year

Topic mentions per year

2014-2017
0246820142017

Papers overview

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2017
2017
Tyrosine kinase inhibitor (TKI) resistance and progression to blast crisis (BC), both related to persistent β-catenin activation… (More)
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2017
2017
BACKGROUND There is currently no anti-fibrotic drug therapy available to treat hepatitis C virus (HCV) cirrhosis. The aim of this… (More)
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2017
2017
Chronic hepatitis C virus (HCV) infection is one of the major causes of serious liver diseases, including liver cirrhosis. There… (More)
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2017
2017
Current pangenotypic direct-acting antivirals (DAA) eradicate moving forward further testing of tolerabilitywith lower doses… (More)
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Review
2017
Review
2017
Wnt/β-catenin pathway is one of the main/frequent dysregulated pathways in several tumor types, including colon cancer. Aberrant… (More)
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Review
2017
Review
2017
Canonical WNT signaling through Frizzled and LRP5/6 receptors is transduced to the WNT/β-catenin and WNT/stabilization of… (More)
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Review
2017
Review
2017
Colorectal cancer (CRC) is the third most frequent malignancy and represents the fourth most common cause of cancer-associated… (More)
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Review
2017
Review
2017
Cancer stem cells (CSCs), which have the potential for self-renewal, differentiation and de-differentiation, undergo epigenetic… (More)
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2015
2015
Wnt/β-catenin is involved in every aspect of embryonic development and in the pathogenesis of many human diseases, and is also… (More)
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Review
2014
Review
2014
Throughout our life, long-lived somatic stem cells (SSC) regenerate adult tissues both during homeostatic processes and repair… (More)
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