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CBP/beta-catenin Antagonist PRI-724

Known as: PRI-724 
A potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Macrophages as an Emerging Source of Wnt Ligands: Relevance in Mucosal Integrity
The Wnt signaling pathway is a conserved pathway involved in important cellular processes such as the control of embryonic… 
2019
2019
The novel inhibitor PRI-724 for Wnt/β-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice
Abstract Purpose/Aim of the Study: Wnt/β-catenin signaling was reported to be activated in pulmonary fibrosis, and was focused on… 
2018
2018
Targeting the Wnt/β-catenin pathway in human osteosarcoma cells
Aberrant activation of Wnt signaling has been implicated in human osteosarcoma, which may provide a genetic vulnerability that… 
Review
2017
Review
2017
Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)
Cancer stem cells (CSCs), which have the potential for self-renewal, differentiation and de-differentiation, undergo epigenetic… 
Review
2017
Review
2017
Therapeutic Potential of Targeting Wnt/β‐Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress
Wnt/β‐catenin pathway is one of the main/frequent dysregulated pathways in several tumor types, including colon cancer. Aberrant… 
Highly Cited
2017
Highly Cited
2017
Combined inhibition of β-catenin and Bcr–Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo
Tyrosine kinase inhibitor (TKI) resistance and progression to blast crisis (BC), both related to persistent β-catenin activation… 
Review
2017
Review
2017
Therapeutic strategies against cancer stem cells in human colorectal cancer
Colorectal cancer (CRC) is the third most frequent malignancy and represents the fourth most common cause of cancer-associated… 
Highly Cited
2015
Highly Cited
2015
Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice
Review
2014
Review
2014
Safely targeting cancer stem cells via selective catenin coactivator antagonism
Throughout our life, long‐lived somatic stem cells (SSC) regenerate adult tissues both during homeostatic processes and repair… 
Highly Cited
2013
Highly Cited
2013
A phase I first-in-human study of PRI-724 in patients (pts) with advanced solid tumors.
2501 Background: PRI-724 is a first-in-class modulator of Wnt signaling that inhibits the CREB binding protein and β-catenin… 
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