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A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected].
ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer. Expand
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
An update on the latest advances in the clinical development of treatment strategies targeting cancer stem cells with rational combinations of agents to inhibit possible compensatory escape mechanisms is provided. Expand
Can we safely target the WNT pathway?
  • M. Kahn
  • Biology, Medicine
  • Nature Reviews Drug Discovery
  • 1 July 2014
The problems and potential solutions to the vexing situation of aberrant regulation of the WNT pathway are examined and a attempt is made to bring them into perspective. Expand
Wnt signaling promotes reprogramming of somatic cells to pluripotency.
Document S1. Supplemental Experimental Procedures, Supplemental References, One Table, and Three FiguresxDownload (.35 MB ) Document S1. Supplemental Experimental Procedures, Supplemental References,Expand
Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?
The Wnt/β-catenin signaling pathway is focused on, which is the most intensively studied and best characterized Wnt signaling pathway and the possibility of the development of novel therapeutics to target this pathway is provided. Expand
Differential roles for the coactivators CBP and p300 on TCF/β-catenin-mediated survivin gene expression
It is demonstrated that CBP and p300 play very distinct roles in survivin gene transcription, the crucial coactivator for TCF/β-catenin-mediated survivin transcription. Expand
Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency
It is demonstrated that IQ-1, by targeting the PR72/130 subunit of the serine/threonine phosphatase PP2A, prevents β-catenin from switching coactivator usage from CBP to p300 and is critical for the maintenance of murine stem cell pluripotency. Expand
Interactions Between β-Catenin and Transforming Growth Factor-β Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response
TGF-β induction of α-smooth muscle actin (α-SMA) involves ternary complex formation among Smad3, β-catenin, and CBP, which suggests a new therapeutic approach to pulmonary fibrosis by specifically uncoupling CBP/ catenin-dependent signaling downstream of TGF- β. Expand
The Wnt signaling pathway in cancer.
A major challenge resides in developing a strategy efficient enough to target the dysregulated Wnt pathway in CSCs, while being safe enough to not damage the normal somatic stem cell population required for tissue homeostasis and repair. Expand
Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression.
This work is the first to show that EphB4 is preferentially induced in colorectal cancer, in contrast to EphEphB2, whereby tumor cells acquire a survival advantage. Expand