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CASP8 gene

Known as: FADD-HOMOLOGOUS ICE/CED3-LIKE PROTEASE, MCH5, FLICE 
This gene is involved in apoptosis, immune cell homeostasis, lymphocyte activation and immunoprotection.
National Institutes of Health

Related topics

Related topics

6 relations
ApoptosisDegenerative Diseases, Central Nervous SystemHydrolysisProteolysis

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CASP8 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival
Caspase 8 can initiate apoptosis, but it also has non-apoptotic roles; for example, it is required for embryonic development and… 
Highly Cited
2010
Highly Cited
2010
Titanium dioxide nanoparticles cause apoptosis in BEAS-2B cells through the caspase 8/t-Bid-independent mitochondrial pathway.
Highly Cited
2008
Highly Cited
2008
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation
We recently noted that low doses of sorafenib and vorinostat interact in a synergistic fashion to kill carcinoma cells by… 
Highly Cited
2007
Highly Cited
2007
Gonadotrophins regulate germ cell survival, not proliferation, in normal adult men.
BACKGROUND Gonadotrophins support spermatogenesis via poorly understood mechanisms. We aimed to determine the effect of FSH/LH… 
Highly Cited
2005
Highly Cited
2005
Death Receptor-Induced Signaling Pathways Are Differentially Regulated by Gamma Interferon Upstream of Caspase 8 Processing
ABSTRACT FasL and gamma interferon (IFN-γ) are produced by activated T cells and NK cells and synergistically induce apoptosis… 
Highly Cited
2005
Highly Cited
2005
Tula hantavirus triggers pro-apoptotic signals of ER stress in Vero E6 cells
Highly Cited
2004
Highly Cited
2004
Absence of Caspase 8 and High Expression of PED Protect Primitive Neural Cells from Cell Death
The mechanisms that control neural stem and progenitor cell survival are unknown. In several pathological conditions, death… 
Highly Cited
2003
Highly Cited
2003
Caspase 8 small interfering RNA prevents acute liver failure in mice
A major concern in therapy of acute liver failure is protection of hepatocytes to prevent apoptosis and maintain liver function… 
Highly Cited
2001
Highly Cited
2001
Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma
We previously reported a high incidence of loss of heterozygosity (LOH) on chromosome 2q33 in neuroblastoma (NB), observed in… 
Highly Cited
2000
Highly Cited
2000
Granzyme B Short-Circuits the Need for Caspase 8 Activity during Granule-Mediated Cytotoxic T-Lymphocyte Killing by Directly Cleaving Bid
ABSTRACT Cytotoxic T lymphocytes (CTL) can trigger an apoptotic signal through the Fas receptor or by the exocytosis of granzyme… 
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