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CASP8 gene

Known as: FADD-HOMOLOGOUS ICE/CED3-LIKE PROTEASE, MCH5, FLICE 
This gene is involved in apoptosis, immune cell homeostasis, lymphocyte activation and immunoprotection.
National Institutes of Health

Related topics

Related topics

6 relations
ApoptosisDegenerative Diseases, Central Nervous SystemHydrolysisProteolysis

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CASP8 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
The protective effect of ischemic preconditioning against hepatic ischemic-reperfusion injury under isoflurane anesthesia in rats.
2008
2008
Direct activation of caspase 8 by the proapoptotic E2 protein of HPV18 independent of adaptor proteins
The self-activation of initiator caspases is dependent on their oligomerization driven by interaction with the death fold domains… 
2007
2007
P60-c-src suppresses apoptosis through inhibition of caspase 8 activation in hepatoma cells, but not in primary hepatocytes.
2007
2007
Exposure to inorganic mercury in vivo attenuates extrinsic apoptotic signaling in Staphylococcal aureus enterotoxin B stimulated T-cells.
Highly Cited
2005
Highly Cited
2005
Death Receptor-Induced Signaling Pathways Are Differentially Regulated by Gamma Interferon Upstream of Caspase 8 Processing
ABSTRACT FasL and gamma interferon (IFN-γ) are produced by activated T cells and NK cells and synergistically induce apoptosis… 
2005
2005
Apoptosis Through Targeted Activation of Caspase8 (“ATTAC-mice”): Novel Mouse Models of Inducible and Reversible Tissue Ablation
Recent studies identifying obesity as a significant and increasingly more common cause of morbidity and mortality have… 
2004
2004
Expression of membrane‐bound and soluble FasL in Fas‐ and FADD‐dependent T lymphocyte apoptosis induced by mildly oxidized LDL
Apoptosis plays an essential role in atherosclerosis. Oxidized low‐density lipoproteins (oxLDL) and activated T lymphocytes are… 
2002
2002
The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a…
Interactions between the histone deacetylase inhibitor sodium butyrate (SB) and phorbol 12-myristate 13-acetate (PMA) were… 
Highly Cited
2001
Highly Cited
2001
Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma
We previously reported a high incidence of loss of heterozygosity (LOH) on chromosome 2q33 in neuroblastoma (NB), observed in… 
2001
2001
Caspase 7 can cleave tumor necrosis factor receptor-I (p60) at a non-consensus motif, in vitro.
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