CASP8 gene

Known as: FADD-HOMOLOGOUS ICE/CED3-LIKE PROTEASE, MCH5, FLICE 
This gene is involved in apoptosis, immune cell homeostasis, lymphocyte activation and immunoprotection.
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
We recently noted that low doses of sorafenib and vorinostat interact in a synergistic fashion to kill carcinoma cells by… (More)
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2006
2006
Human herpesvirus 8 (HHV-8) encodes a viral FLICE inhibitory protein (vFLIP), called K13, with homology to the prodomain of… (More)
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Highly Cited
2004
Highly Cited
2004
The mechanisms that control neural stem and progenitor cell survival are unknown. In several pathological conditions, death… (More)
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Highly Cited
2004
Highly Cited
2004
AbstractDifferentiation of human placental villous trophoblast includes syncytial fusion of cytotrophoblast forming… (More)
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Highly Cited
2003
Highly Cited
2003
Phagocytosis of complement-opsonized targets is a primary function of neutrophils at sites of inflammation, and the clearance of… (More)
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Highly Cited
2003
Highly Cited
2003
Defects in death receptor-mediated apoptosis have been linked to cancer and autoimmune disease in humans. The in vivo role of… (More)
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2003
2003
Macrophage apoptosis is an important component of the innate immune defense machinery (against pathogenic mycobacteria… (More)
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2002
2002
Interactions between the histone deacetylase inhibitor sodium butyrate (SB) and phorbol 12-myristate 13-acetate (PMA) were… (More)
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Highly Cited
2000
Highly Cited
2000
Cytotoxic T lymphocytes (CTL) can trigger an apoptotic signal through the Fas receptor or by the exocytosis of granzyme B and… (More)
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2000
2000
Arsenic trioxide (As2O3)-treatment is effective in acute promyelocytic leukemia (APL) patients with t(15;17). Clinically… (More)
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