CASP3 gene

Known as: CPP32B, CPP32, caspase 3 
This gene plays a role in the execution phase of apoptosis and is involved in DNA repair.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1954-2017
0519542016

Papers overview

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2004
2004
Failure of apoptosis is one of the hallmarks of cancer. As an execution-phase caspase, caspase-3 plays a crucial role during… (More)
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2000
2000
We investigated the cytotoxic responsiveness of 40 cell lines derived from representatives of the Ewing's sarcoma family of… (More)
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Highly Cited
1998
Highly Cited
1998
The mechanisms by which immature thymocyte apoptosis is induced during negative selection are poorly defined. Reports… (More)
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1998
1998
In this study we show that TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), also called Apo2L, activates the c… (More)
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1997
1997
Poly(ADP-ribose) polymerase (PARP), which is catalytically activated by DNA strand breaks, has been implicated in apoptosis, or… (More)
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Highly Cited
1996
Highly Cited
1996
Proteolysis mediated by the interleukin 1 beta-converting enzyme (ICE) homologues is an important mechanism of the apoptotic… (More)
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Highly Cited
1996
Highly Cited
1996
Apoptosis has recently been recognized as a mode of cell death in Huntington disease (HD). Apopain, a human counterpart of the… (More)
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Highly Cited
1996
Highly Cited
1996
Cysteine proteases of the interleukin 1 beta Converting Enzyme (ICE)/CED-3 family have been implicated in the effector process of… (More)
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Highly Cited
1996
Highly Cited
1996
Phylogenetic analysis of the CED-3/ICE family of cysteine proteases suggests the existence of a subfamily most related to the… (More)
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Highly Cited
1995
Highly Cited
1995
The protease responsible for the cleavage of poly(ADP-ribose) polymerase and necessary for apoptosis has been purified and… (More)
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