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The modular SCF (Skp1, cullin, and F box) ubiquitin ligases feature a large family of F box protein substrate receptors that… Expand Cullin-RING ligases (CRLs) compose the largest class of E3 ubiquitin ligases. CRLs are modular, multisubunit enzymes, comprising… Expand Dynamic reorganization of signaling systems frequently accompanies pathway perturbations, yet quantitative studies of network… Expand Genome-wide association studies (GWAS) have gained considerable momentum over the last couple of years for the identification of… Expand The COP9 signalosome (CSN) is thought to maintain the stability of cullin-RING ubiquitin ligases (CRL) by limiting the… Expand The SCF ubiquitin ligase complex regulates diverse cellular functions by ubiquitinating numerous protein substrates. Cand1, a 120… Expand Ubiquitin/proteasome-mediated protein degradation controls various developmental pathways in eukaryotes. Cullin-containing… Expand Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse… Expand The SCF ubiquitin E3 ligase regulates ubiquitin-dependent proteolysis of many regulatory proteins such as p27(Kip1), IkappaB, and… Expand Cullin proteins assemble a large number of RING E3 ubiquitin ligases and regulate various physiological processes. Covalent… Expand