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C1GALT1C1 gene

Known as: C1GALT1C1, CORE 1 BETA-3-GALACTOSYLTRANSFERASE-SPECIFIC MOLECULAR CHAPERONE, C1GALT2 
This gene plays a role as a chaperone in generation of the common core 1 O-glycan structure.
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Aberrant O-glycosylation of serum immunoglobulin A1 (IgA1) represents a heritable pathogenic defect in IgA nephropathy, the most… 
Highly Cited
2015
Highly Cited
2015
BackgroundHuman pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies in the world and… 
Highly Cited
2014
Highly Cited
2014
Chinese hamster ovary (CHO) cells are widely used in the biopharmaceutical industry as a host for the production of complex… 
Highly Cited
2012
Highly Cited
2012
Background: Tn4 B cells from a patient with Tn antigen-positive leukocytes lack transcripts of Cosmc. Results: The Cosmc promoter… 
Highly Cited
2011
Highly Cited
2011
Mucin-type O-linked oligosaccharides (O-glycans) are primary components of the intestinal mucins that form the mucus gel layer… 
2011
2011
The molecular basis for retention of integral membrane proteins in the endoplasmic reticulum (ER) is not well understood. We… 
Highly Cited
2010
Highly Cited
2010
Cosmc is a molecular chaperone thought to be required for expression of active T-synthase, the only enzyme that galactosylates… 
Highly Cited
2008
Highly Cited
2008
Regulatory pathways for protein glycosylation are poorly understood, but expression of branchpoint enzymes is critical. A key… 
2008
2008
Tn polyagglutination results from inactivating mutations in C1GALT1C1, an X‐borne gene encoding a core 1 β3‐galactosyltransferase… 
Highly Cited
2002
Highly Cited
2002
Human core 1 β3-galactosyltransferase (C1β3Gal-T) generates the core 1 O-glycan Galβ1-3GalNAcα1-Ser/Thr (T antigen), which is a…