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C1GALT1C1 gene

Known as: C1GALT1C1, CORE 1 BETA-3-GALACTOSYLTRANSFERASE-SPECIFIC MOLECULAR CHAPERONE, C1GALT2 
This gene plays a role as a chaperone in generation of the common core 1 O-glycan structure.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
BackgroundHuman pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies in the world and… Expand
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Highly Cited
2014
Highly Cited
2014
Chinese hamster ovary (CHO) cells are widely used in the biopharmaceutical industry as a host for the production of complex… Expand
2014
2014
Background: We hypothesize that ER chaperone Cosmc binds specifically to its single client T-synthase. Results: Using molecular… Expand
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Highly Cited
2012
Highly Cited
2012
Background: Tn4 B cells from a patient with Tn antigen-positive leukocytes lack transcripts of Cosmc. Results: The Cosmc promoter… Expand
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Highly Cited
2011
Highly Cited
2011
  • J. Fu, B. Wei, +14 authors L. Xia
  • The Journal of clinical investigation
  • 2011
  • Corpus ID: 25878036
Mucin-type O-linked oligosaccharides (O-glycans) are primary components of the intestinal mucins that form the mucus gel layer… Expand
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Highly Cited
2010
Highly Cited
2010
  • Y. Wang, T. Ju, +5 authors R. Cummings
  • Proceedings of the National Academy of Sciences
  • 2010
  • Corpus ID: 34374349
Cosmc is a molecular chaperone thought to be required for expression of active T-synthase, the only enzyme that galactosylates… Expand
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Highly Cited
2008
Highly Cited
2008
Regulatory pathways for protein glycosylation are poorly understood, but expression of branchpoint enzymes is critical. A key… Expand
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2008
2008
Tn polyagglutination results from inactivating mutations in C1GALT1C1, an X‐borne gene encoding a core 1 β3‐galactosyltransferase… Expand
Highly Cited
2007
Highly Cited
2007
IgA nephropathy (IgAN) is a polygenic disorder and the precise role of genetic factors remains elusive. Increasing evidences have… Expand
Highly Cited
2002
Highly Cited
2002
  • T. Ju, R. Cummings
  • Proceedings of the National Academy of Sciences…
  • 2002
  • Corpus ID: 7920047
Human core 1 β3-galactosyltransferase (C1β3Gal-T) generates the core 1 O-glycan Galβ1-3GalNAcα1-Ser/Thr (T antigen), which is a… Expand
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