Symbol Nomenclature for Graphical Representations of Glycans.
Author(s): Varki, Ajit; Cummings, Richard D; Aebi, Markus; Packer, Nicole H; Seeberger, Peter H; Esko, Jeffrey D; Stanley, Pamela; Hart, Gerald; Darvill, Alan; Kinoshita, Taroh; Prestegard, James J;…
Involvement of the Snake Toxin Receptor CLEC-2, in Podoplanin-mediated Platelet Activation, by Cancer Cells*♦
It is suggested that CLEC-2 is a physiological target protein of podoplanin and imply that it is involved in podoplanIn-induced platelet aggregation, tumor metastasis, and other cellular responses related to podoplan in.
A serum “sweet-doughnut” protein facilitates fibrosis evaluation and therapy assessment in patients with viral hepatitis
A glycan-based immunoassay, FastLec-Hepa, is the only assay currently available for clinically beneficial therapy evaluation through quantitation of disease severity and is sufficiently sensitive and quantitative to evaluate the effects of PEG-interferon-α/ribavirin therapy in a short post-therapeutic interval.
Molecular Genetic Analysis of the Human Lewis Histo-blood Group System
The results show that the Sec2 gene really encodes the secretor enzyme α(1,2)fucosyltransferase and indicate that a ethnic group-specific nonsense or missense point mutation in theSec2 gene determines nonsecretor status.
Lewis and secretor gene dosages affect CA19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients.
The revised Le and Se genotype-dependent positive/negative cutoff values for CA19-9 and DU-PAN-2, determined in this study, be applied for more accurate cancer diagnoses and should be performed in Le-negative patients for cancer diagnosis.
Noroviruses Distinguish between Type 1 and Type 2 Histo-Blood Group Antigens for Binding
The results indicated that the type 1 carbohydrates bind more tightly to NoV VLPs than the type 2 carbohydrates, which may afford NoV tissue specificity.
α1,3‐Fucoslytransferase IX (Fuc‐TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc‐TIX
Deletion polymorphism of SIGLEC14 and its functional implications.
It is found that a fusion between SIGlec14 and SIGleC5 genes, resulting in the functional deletion of SIGLEC14, underlies this phenotype, and implies that Siglec-14 may play some role in bacterial infection.
Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study.
The results of this multi-institutional study indicate that MS-based analysis appears as the efficient method for identification and quantitation of oligosaccharides in glycomic studies and endorse the power of MS for glycopeptide characterization with high sensitivity in proteomic programs.
Molecular Cloning and Identification of 3′-Phosphoadenosine 5′-Phosphosulfate Transporter*
A novel human gene encoding a PAPS transporter, which is named PAPST1, and the Drosophila melanogaster ortholog, slalom (sll), is identified and insights into the significance of PAPS transport and post-translational sulfation are provided.