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Involvement of the Snake Toxin Receptor CLEC-2, in Podoplanin-mediated Platelet Activation, by Cancer Cells*♦
It is suggested that CLEC-2 is a physiological target protein of podoplanin and imply that it is involved in podoplanIn-induced platelet aggregation, tumor metastasis, and other cellular responses related to podoplan in. Expand
Symbol Nomenclature for Graphical Representations of Glycans.
Author(s): Varki, Ajit; Cummings, Richard D; Aebi, Markus; Packer, Nicole H; Seeberger, Peter H; Esko, Jeffrey D; Stanley, Pamela; Hart, Gerald; Darvill, Alan; Kinoshita, Taroh; Prestegard, James J;Expand
Molecular Genetic Analysis of the Human Lewis Histo-blood Group System
The results show that the Sec2 gene really encodes the secretor enzyme α(1,2)fucosyltransferase and indicate that a ethnic group-specific nonsense or missense point mutation in theSec2 gene determines nonsecretor status. Expand
α1,3‐Fucoslytransferase IX (Fuc‐TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc‐TIX
The amino acid sequence of Fuc‐TIX is very highly conserved between mouse and human. The number of non‐synonymous nucleotide substitutions of the Fuc‐TIX gene between human and mouse was strikinglyExpand
Molecular Cloning and Identification of 3′-Phosphoadenosine 5′-Phosphosulfate Transporter*
A novel human gene encoding a PAPS transporter, which is named PAPST1, and the Drosophila melanogaster ortholog, slalom (sll), is identified and insights into the significance of PAPS transport and post-translational sulfation are provided. Expand
Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study.
The results of this multi-institutional study indicate that MS-based analysis appears as the efficient method for identification and quantitation of oligosaccharides in glycomic studies and endorse the power of MS for glycopeptide characterization with high sensitivity in proteomic programs. Expand
Lewis and secretor gene dosages affect CA19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients.
The revised Le and Se genotype-dependent positive/negative cutoff values for CA19-9 and DU-PAN-2, determined in this study, be applied for more accurate cancer diagnoses and should be performed in Le-negative patients for cancer diagnosis. Expand
Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens.
The long-form cDNA of the human ST6GalNAc I gene encodes the probable candidate for the human sTn synthase(s), and in situ hybridization demonstrated that the localization of transcripts correlated well with that of s Tn antigen in gastric cancer cells and Goblet cells in intestinal metaplastic glands. Expand
Noroviruses Distinguish between Type 1 and Type 2 Histo-Blood Group Antigens for Binding
The results indicated that the type 1 carbohydrates bind more tightly to NoV VLPs than the type 2 carbohydrates, which may afford NoV tissue specificity. Expand
A serum “sweet-doughnut” protein facilitates fibrosis evaluation and therapy assessment in patients with viral hepatitis
A glycan-based immunoassay, FastLec-Hepa, is the only assay currently available for clinically beneficial therapy evaluation through quantitation of disease severity and is sufficiently sensitive and quantitative to evaluate the effects of PEG-interferon-α/ribavirin therapy in a short post-therapeutic interval. Expand