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A reservoir-type transdermal delivery system (TDS) of bupranolol (BPL) was designed and evaluated for different formulation… Expand Background—The therapeutic effects of nonspecific β-blockers are limited by vasoconstriction, thus justifying the interest in… Expand Transdermal absorption of drugs is limited by the stratum corneum, which serves as a diffusion barrier. This barrier might be… Expand Bupranolol (BPL) is a potent beta-blocking agent, the extensive first-pass metabolism (>90%) and rapid elimination half-life (1.5… Expand Abstract— Altered expression and functional responses to cardiac &bgr;3-adrenergic receptors (ARs) may contribute to progressive… Expand PURPOSE
To investigate the presence of the beta3-adrenoceptor (beta3-AR) in human and rat detrusor muscle and the usefulness of… Expand Abstract Numerous synthetic agonists selectively stimulate β3-adrenoceptors (ARs). The endogenous catecholamines, noradrenaline… Expand The role of beta3- and other putative atypical beta-adrenoceptors in human white adipocytes and right atrial appendage has been… Expand Beta3-adrenoceptors are involved in metabolism, gut relaxation, and vascular vasodilation. However, their existence and role in… Expand With respect to the beta 1- and beta 2-adrenergic receptors (ARs), the beta 3-AR induces specific physiological effects in a few… Expand