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Molecular Architecture of the Human Sinus Node: Insights Into the Function of the Cardiac Pacemaker
Background— Although we know much about the molecular makeup of the sinus node (SN) in small mammals, little is known about it in humans. The aims of the present study were to investigate theExpand
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Acquired neuromyotonia: Evidence for autoantibodies directed against K+ channels of peripheral nerves
Acquired neuromyotonia is characterized by hyperexcitability of motor nerves leading to muscle twitching, cramps, and weakness. The symptoms may improve following plasma exchange, and injection ofExpand
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Differences between the third cardiac β‐adrenoceptor and the colonic β3‐adrenoceptor in the rat
1 The heart of several species including man contains atypical β‐adrenoceptors, in addition to coexisting β1‐ and β2‐adrenoceptors. We now asked the question whether or not the third cardiacExpand
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Adaptation of quantal content to decreased postsynaptic sensitivity at single endplates in alpha‐bungarotoxin‐treated rats.
1. Rats were injected once every 48 h with alpha‐bungarotoxin (alpha BTX) for periods up to 6 weeks. Injections caused weakness of facial muscles which lasted about 8 h. Hemidiaphragms were dissectedExpand
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Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice
Myotonic dystrophy (DM) is commonly associated with CTG repeat expansions within the gene for DM–protein kinase (DMPK). The effect of altered expression levels of DMPK, which is ubiquitouslyExpand
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Increased Noise Level of Purkinje Cell Activities Minimizes Impact of Their Modulation during Sensorimotor Control
While firing rate is well established as a relevant parameter for encoding information exchanged between neurons, the significance of other parameters is more conjectural. Here, we show thatExpand
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Acetylcholine release in myasthenia gravis: Regulation at single end‐plate level
In myasthenia gravis, loss of acetylcholine receptors at motor end‐plates is induced by antireceptor autoantibodies. At end‐plates in rats in which myasthenia gravis–like symptoms are induced byExpand
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The human heart endothelin system: ET-1 synthesis, storage, release and effect.
Endothelin-1 (ET-1) is synthesized, stored and released in the human heart. On release, ET-1 has the potential to activate specific receptors in a paracrine manner to modify heart function directly.Expand
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Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure.
Human urotensin-II (hU-II) is the most potent endogenous cardiostimulant identified to date. We therefore determined whether hU-II has a possible pathological role by investigating its levels inExpand
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Complex Gangliosides at the Neuromuscular Junction Are Membrane Receptors for Autoantibodies and Botulinum Neurotoxin But Redundant for Normal Synaptic Function
One specialization of vertebrate presynaptic neuronal membranes is their multifold enrichment in complex gangliosides, suggesting that these sialoglycolipids may play a major functional role inExpand
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