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Acquired neuromyotonia: Evidence for autoantibodies directed against K+ channels of peripheral nerves
TLDR
It is concluded that at least some patients with acquired neuromyotonia have antibodies directed against aminopyridine‐ or α‐dendrotoxin‐sensitive K+ channels in motor and sensory neurons, and they are likely to be implicated in the disease process.
Molecular Architecture of the Human Sinus Node: Insights Into the Function of the Cardiac Pacemaker
TLDR
Ion channels show a complex and heterogeneous pattern of expression in the SN, paranodal area, and RA in humans, and the expression pattern is appropriate to explain pacemaking.
Differences between the third cardiac β‐adrenoceptor and the colonic β3‐adrenoceptor in the rat
TLDR
The properties of the third cardiac β‐adrenoceptor are compared with those of β3‐ adrenoceptors in isolated tissues of the rat using spontaneously beating right atria, paced left atria and paced left ventricular papillary muscle precontracted with 30 mM KCl.
Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice
TLDR
The contention that simple loss– or gain–of–expression of DMPK is not the only crucial requirement for development of the disease is strengthened.
Acetylcholine release in myasthenia gravis: Regulation at single end‐plate level
TLDR
In both human and rat autoimmune myasthenic muscle, the mean quantal content was considerably increased compared with control levels, and this finding suggests the existence of an important compensatory mechanism inMyasthenia gravis, in which retrograde acting factors upregulate acetylcholine release.
The human heart endothelin system: ET-1 synthesis, storage, release and effect.
Complex Gangliosides at the Neuromuscular Junction Are Membrane Receptors for Autoantibodies and Botulinum Neurotoxin But Redundant for Normal Synaptic Function
TLDR
Data prove the critical importance of complex gangliosides in mediating pathophysiological events at the neuromuscular synapse by showing that they are membrane receptors for both the paralytic botulinum neurotoxin type-A and human neuropathy-associated anti-ganglioside autoantibodies that arise through molecular mimicry with microbial structures.
Antibody effector mechanisms in myasthenia gravis—Pathogenesis at the neuromuscular junction
TLDR
Findings suggest that MuSK-MG may be different in etiological and pathological mechanisms from AChR-MG, and the effector functions of IgG subclasses on synapse structure and function are discussed in this review.
Arg389Gly-&bgr;1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol
TLDR
In patients with nonischemic dilated cardiomyopathy, carvedilol leads to a significantly greater improvement in left ventricular ejection fraction (LVEF) in patients with the Arg389Arg-&bgr;1 adrenergic receptor phenotype.
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