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Eicosanoid‐induced Ca2+ release and sustained contraction in Ca2+‐free media are mediated by different signal transduction pathways in rat aorta
TLDR
The sustained contractions evoked by the eicosanoids in Ca2+‐free solution were potentiated, suggesting that the sites of actions of β‐TPA and the eicsanoids may differ from each other.
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Pharmacological properties of electrical activities obtained from neurons in Auerbach's plexus.
TLDR
The findings indicate that the single-spike unit is concerned with cholinergic transmission in Auerbach’s plexus and indicated the possibility that morphine and the α-adrenergic stimulants also inhibit the acetylcholine release from the Cholinergic nerve at the ending of the post-ganglionic fibres.
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Signal transduction pathway involved in beta 3-adrenoceptor-mediated relaxation in guinea pig taenia caecum.
TLDR
The results suggest that the production of cyclic AMP contributes to the beta 3-adrenoceptor (or atypical beta-adRenoceptor)-mediated relaxation of the guinea pig taenia caecum.
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Differentiation of binding sites of CGP12177, aβ3-adrenoceptor partial agonist, and carteolol, a β1/β2-adrenoceptor partial agonist, to the β-adrenoceptors in guinea-pig taenia caecum
On a examine la differenciation des sites de fixation du CGP12177 et du carteolol aux adrenorecepteurs-β dans le taenia caecum de cobayes. Le carteolol et le CGP12177 ont antagonise de maniere…
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Possible involvement of substance P immunoreactive nerves in the mediation of nicotine-induced contractile responses in isolated guinea pig bronchus.
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Antiphosphodiesterase activity and nonspecific smooth muscle relaxation tested on intestinal smooth muscles.
TLDR
Papaverine and Aspaminol (1, 1-diphenyl-3-piperidinobutanol hydrochloride), hydralazine, caffeine Na benzoate and aminophylline were used at test drugs and there was little correlation between relaxing activities of the drugs used and their antiphosphodiesterase activities.
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Intracellular cyclic adenosine 3', 5'-monophosphate and relaxing effects of isoprenaline and papaverine on smooth muscle of intestine.
TLDR
The results indicate the possibilities that the actions of beta-adrenergic stimulants and papaverine are mediated through an increase of the intracellular level of cyclic AMP and that cyclicAMP is not concerned with the response to alpha-adenergic stimulant.
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Effects of nonspecific smooth muscle relaxants and Ca-blocker on Ca-release and Ca-binding in microsomal fractions from rabbit taenia coli.
TLDR
Effects of nonspecific smooth muscle relaxants and Aspaminol on Ca-release and Ca-binding in the microsomal fractions of rabbit taenia coli were determined and changes observed in Ca-transfer may be related to relaxation of smooth muscle induced by the test drugs.
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Muscarinic acetylcholine receptors in the rabbit ciliary body smooth muscle: spare receptors and threshold phenomenon.
TLDR
Interactions of several muscarinic drugs with their receptors were studied in the ciliary body smooth muscles of the rabbit, and atropine produced a parallel shift to the right in the concentration-response curves for carbachol.
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Involvement of botulinum C3-sensitive GTP-binding proteins in alpha 1-adrenoceptor subtypes mediating Ca(2+)-sensitization.
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