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Eicosanoid‐induced Ca2+ release and sustained contraction in Ca2+‐free media are mediated by different signal transduction pathways in rat aorta
The sustained contractions evoked by the eicosanoids in Ca2+‐free solution were potentiated, suggesting that the sites of actions of β‐TPA and the eicsanoids may differ from each other.
Pharmacological properties of electrical activities obtained from neurons in Auerbach's plexus.
The findings indicate that the single-spike unit is concerned with cholinergic transmission in Auerbach’s plexus and indicated the possibility that morphine and the α-adrenergic stimulants also inhibit the acetylcholine release from the Cholinergic nerve at the ending of the post-ganglionic fibres.
Signal transduction pathway involved in beta 3-adrenoceptor-mediated relaxation in guinea pig taenia caecum.
The results suggest that the production of cyclic AMP contributes to the beta 3-adrenoceptor (or atypical beta-adRenoceptor)-mediated relaxation of the guinea pig taenia caecum.
Differentiation of binding sites of CGP12177, aβ3-adrenoceptor partial agonist, and carteolol, a β1/β2-adrenoceptor partial agonist, to the β-adrenoceptors in guinea-pig taenia caecum
On a examine la differenciation des sites de fixation du CGP12177 et du carteolol aux adrenorecepteurs-β dans le taenia caecum de cobayes. Le carteolol et le CGP12177 ont antagonise de maniere…
Possible involvement of substance P immunoreactive nerves in the mediation of nicotine-induced contractile responses in isolated guinea pig bronchus.
Antiphosphodiesterase activity and nonspecific smooth muscle relaxation tested on intestinal smooth muscles.
Papaverine and Aspaminol (1, 1-diphenyl-3-piperidinobutanol hydrochloride), hydralazine, caffeine Na benzoate and aminophylline were used at test drugs and there was little correlation between relaxing activities of the drugs used and their antiphosphodiesterase activities.
Intracellular cyclic adenosine 3', 5'-monophosphate and relaxing effects of isoprenaline and papaverine on smooth muscle of intestine.
- I. Takayanagi, M. Uchida, N. Inatomi, A. Tomiyama, K. Takagi
- BiologyJapanese journal of pharmacology
The results indicate the possibilities that the actions of beta-adrenergic stimulants and papaverine are mediated through an increase of the intracellular level of cyclic AMP and that cyclicAMP is not concerned with the response to alpha-adenergic stimulant.
Effects of nonspecific smooth muscle relaxants and Ca-blocker on Ca-release and Ca-binding in microsomal fractions from rabbit taenia coli.
- I. Takayanagi, T. Hisayama, S. Suzuki
- Biology, ChemistryJapanese journal of pharmacology
- 1 October 1980
Effects of nonspecific smooth muscle relaxants and Aspaminol on Ca-release and Ca-binding in the microsomal fractions of rabbit taenia coli were determined and changes observed in Ca-transfer may be related to relaxation of smooth muscle induced by the test drugs.
Muscarinic acetylcholine receptors in the rabbit ciliary body smooth muscle: spare receptors and threshold phenomenon.
Interactions of several muscarinic drugs with their receptors were studied in the ciliary body smooth muscles of the rabbit, and atropine produced a parallel shift to the right in the concentration-response curves for carbachol.