I. Takayanagi

Publications415
h-index24
Citations3,220
Highly Influential Citations33
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Pharmacological properties of electrical activities obtained from neurons in Auerbach's plexus.
Abstract Two kinds of spikes, a single-spike unit and burst unit, were obtained by a glass suction electrode recording from neurons in Auerbach’s plexus of the guinea pig ileum. Both spikes were… Expand
Eicosanoid‐induced Ca2+ release and sustained contraction in Ca2+‐free media are mediated by different signal transduction pathways in rat aorta
1 The effects of 12‐O‐tetradecanoyl 4β‐phorbol 13‐acetate (β‐TPA) on the inositol 1,4,5‐trisphosphate (IP3) production, Ca2+ release from the intracellular Ca2+ stores and sensitization of… Expand
Signal transduction pathway involved in beta 3-adrenoceptor-mediated relaxation in guinea pig taenia caecum.
Experiments were carried out to examine the components of the intracellular second messenger system that is involved in beta 3-adrenoceptor (atypical beta-adrenoceptors)-mediated relaxation in the… Expand
Possible involvement of substance P immunoreactive nerves in the mediation of nicotine-induced contractile responses in isolated guinea pig bronchus.
Nicotine-induced contraction of the isolated guinea pig bronchial preparation was abolished by capsaicin and a substance P (SP) antagonist [( D-Arg1,D-Pro2,D-Trp7,9,Leu11]SP). Nicotine increased the… Expand
Antiphosphodiesterase activity and nonspecific smooth muscle relaxation tested on intestinal smooth muscles.
Mitochondrial, microsomal and soluble fractions separated from the guinea pig taenia and from the dog longitudinal smooth muscle were used as phosphodiesterase preparation. Each preparation had low… Expand
Effects of nonspecific smooth muscle relaxants and Ca-blocker on Ca-release and Ca-binding in microsomal fractions from rabbit taenia coli.
Effects of nonspecific smooth muscle relaxants, papaverine (10(-4) M) and Aspaminol (1,1-diphenyl-3-piperidinobutanol hydrochloride, 10(-4) M), and Ca-blocker, D-600 (10(-6) M) on Ca-release and… Expand
Intracellular cyclic adenosine 3', 5'-monophosphate and relaxing effects of isoprenaline and papaverine on smooth muscle of intestine.
Abstract The beta-adrenergic action is thought to be related to the ability of the beta-adrenergic stimulants to increase the intracellular level of cyclic adenosine 3’,5’-monophosphate (cyclic AMP)… Expand
Muscarinic acetylcholine receptors in the rabbit ciliary body smooth muscle: spare receptors and threshold phenomenon.
Interactions of several muscarinic drugs with their receptors were studied in the ciliary body smooth muscles of the rabbit. The ciliary body smooth muscles responded to carbachol, a muscarinic full… Expand
Involvement of botulinum C3-sensitive GTP-binding proteins in alpha 1-adrenoceptor subtypes mediating Ca(2+)-sensitization.
The mechanisms of alpha 1-adrenoceptor agonist-mediated sensitization of the contractile apparatus of smooth muscle to Ca2+ were studied in beta-escin-permeabilized thoracic arterial smooth muscle of… Expand
Action of nicotine on guinea-pig isolated bronchial smooth muscle preparation.
In the isolated bronchial preparation of the guinea-pig, nicotine induced a contraction but not a relaxation. The contractile response of the bronchial preparation to nicotine was inhibited by… Expand
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