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Bepridil

Known as: 1-(2-(N-Benzylanilino)-1-(Isobutoxymethyl)Ethyl)-Pyrrolidine, 1-Pyrrolidineethanamine, beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-, 1-Pyrrolideneethanamine, Beta-((2-Methylpropoxy)Methyl)-N-Phenyl-N-(Phenylmethyl)- 
A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest… 
National Institutes of Health

Related topics

Related topics

29 relations

Narrower (6)

11888CERMBepridil hydrochlorideCERM-1978McN 6303
AdenosineAmprenavirAngina PectorisCalcium Channel Antagonists [MoA]

Broader (4)

Anti-Arrhythmia AgentsAntihypertensive AgentsCalcium Channel BlockersVasodilator Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1999
Highly Cited
1999
Bepridil differentially inhibits two delayed rectifier K+ currents, IKr and IKs, in guinea‐pig ventricular myocytes
We investigated the effects of bepridil on the two components of the delayed rectifier K+ current, i.e., the rapidly activating… 
Highly Cited
1988
Highly Cited
1988
Protection of cardiac membrane phospholipid against oxidative injury by calcium antagonists.
Highly Cited
1988
Highly Cited
1988
Inhibition of sodium-calcium exchange in cardiac sarcolemmal membrane vesicles. 2. Mechanism of inhibition by bepridil.
Bepridil, an antiarrhythmic agent, inhibits Na-Ca exchange in cardiac sarcolemmal membrane vesicles (Ki = 30 microM) by a novel… 
Highly Cited
1987
Highly Cited
1987
A comparison of bepridil with amiodarone in the treatment of established atrial fibrillation.
Fourteen patients with established atrial fibrillation (longer than three months) that was refractory to treatment were studied… 
1985
1985
Pharmacology of calcium antagonists.
Highly Cited
1984
Highly Cited
1984
Uptake of calcium antagonistic drugs into muscles as related to their lipid solubilities.
1984
1984
[3H] verapamil binding sites in skeletal muscle transverse tubule membranes.
Highly Cited
1984
Highly Cited
1984
Effects of bepridil on the electrophysiological properties of guinea‐pig ventricular muscles
1 Effects of bepridil, a new antianginal and potential antiarrhythimic agent, on transmembrane action potentials of ventricular… 
1984
1984
Activation of the voltage-dependent Ca2+ channel in rat heart cells by dihydropyridine derivatives.
Highly Cited
1981
Highly Cited
1981
Bepridil Blockade of Ca2+-Dependent Action Potentials in Vascular Smooth Muscle of Dog Coronary Artery
Summary The effect of the new vasodilatory and antianginal compound, bepridil (CERM-1978), was examined on the electrical… 
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