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Bepridil

Known as: 1-(2-(N-Benzylanilino)-1-(Isobutoxymethyl)Ethyl)-Pyrrolidine, 1-Pyrrolidineethanamine, beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-, 1-Pyrrolideneethanamine, Beta-((2-Methylpropoxy)Methyl)-N-Phenyl-N-(Phenylmethyl)- 
A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest… 
National Institutes of Health

Related topics

Related topics

29 relations

Narrower (6)

11888CERMBepridil hydrochlorideCERM-1978McN 6303
AdenosineAmprenavirAngina PectorisCalcium Channel Antagonists [MoA]

Broader (4)

Anti-Arrhythmia AgentsAntihypertensive AgentsCalcium Channel BlockersVasodilator Agents

Papers overview

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Highly Cited
1987
Highly Cited
1987
A comparison of bepridil with amiodarone in the treatment of established atrial fibrillation.
Fourteen patients with established atrial fibrillation (longer than three months) that was refractory to treatment were studied… 
1986
1986
Comparative Electrophysiological Effects of Disopyramide and Bepridil on Rabbit Atrial, Papillary, and Purkinje Tissue: Modification by Reduced Extracellular Potassium
The electrophysiological actions of bepridil were compared with those of disopyramide in rabbit atrial, Purkinje, and papillary… 
1985
1985
Effect of bepridil in patients with chronic stable angina: results of a multicenter trial.
The effects of bepridil, a calcium antagonist with a half-life of approximately 42 hr, were assessed in a double-blind… 
1985
1985
Effects of verapamil and bepridil on occlusion and reperfusion arrhythmias in the canine heart.
The effects of verapamil and bepridil on occlusion and reperfusion ventricular arrhythmias including ventricular fibrillation (VF… 
1984
1984
Multiple binding of bepridil in human blood.
Using radiolabelled bepridil, equilibrium dialysis experiments and direct ligand-binding studies were conducted to characterize… 
1982
1982
Comparison of [3H]Bepridil and [3H]Verapamil Uptake into Rabbit Aortic Rings
Summary The efflux and uptake of (3H]Ca antagonists were studied in isolated rings of rabbit aorta. The efflux of [3H]bepridil… 
1981
1981
Supraventricular Antidysrhythmic and Electrophysiological Effects of Bepridil, a New Antianginal Agent
Summary We investigated the potential antidysrhythmic effects of bepridil, a new antianginal agent, on dysrhythmias of… 
1981
1981
Comparative antidysrhythmic profiles of bepridil, amiodarone and disopyramide in the guinea-pig and dog.
The antiarrhythmic effects of a novel antianginal agent, bepridil, were compared with four reference products. Bepridil increased… 
1978
1978
Comparative effects of amiodarone, perhexiline and bepridil on the cardiac rhythms of the unanesthetized dog in chronic heart block.
The effects of amiodarone, perhexiline and bepridil, which decrease effort cardioacceleration although they have no adrenergic… 
1977
1977
Cardiovascular pharmacology of bepridil (1[3 isobutoxy 2 (benzylphenyl) amino] propyl pyrrolidine hydrochloride) a new potential anti-anginal compound.
In dogs intravenous bepridil (2.5 mg/kg) increased coronary sinus blood flow and PVO2. Arterial pressure was briefly lowered, and…