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The sigma receptor was originally proposed to be a subtype of the opioid receptor. However, it is now clear that sigma receptors… Expand The σ receptor was originally proposed to be a subtype of the opioid receptor. However, it is now clear that σ receptors are… Expand The brain σ-1 receptors can bind neurosteroids and psychotropic drugs, including neuroleptics and cocaine and are implicated in… Expand We describe a highly efficient, general strategy for the enantioselective synthesis of benzomorphans (45-46% overall yield from… Expand The sigma receptor is a neuronal substrate that binds several psychoactive compounds. These include cocaine, some steroids… Expand At least three different families of endogenous opioid peptides, the enkephalins, endorphins and dynorphins, are present in the… Expand The hypothesis that the nociceptive state and opiate-induced antinociception are generally regulated by Ca2+ brain levels has… Expand The benzomorphans, ethylketazocine, bremazocine and MR 2034 are pure agonists in the guinea‐pig ileum and mouse vas deferens but… Expand [3H]Phencyclidine ([3H]PCP) binds specifically to an apparently single class of binding sites on slide-mounted sections of rat… Expand 1 Four benzomorphans which have potent antinociceptive activity in the hot‐plate and writhing tests in the mouse but do not… Expand