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Benzomorphans

Known as: Benzomorphans [Chemical/Ingredient] 
Morphine derivatives of the methanobenzazocine family that act as potent analgesics.
National Institutes of Health

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Papers overview

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2011
2011
Ethylene in organic synthesis: a new route to anticholenergic pyrrolidinoindolines, and other molecules with all carbon-quaternary centers via asymmetric hydrovinylation.
The asymmetric hydrovinylation (1 mol % Ni-cat., 1 atm, ethylene, >98% ee) products from 1-methylenetetralines are readily… 
2003
2003
Migratory hydroamination: a facile enantioselective synthesis of benzomorphans.
We describe a highly efficient, general strategy for the enantioselective synthesis of benzomorphans (45-46% overall yield from… 
1995
1995
Effects of sigma receptor ligands on the extracellular concentration of dopamine in the striatum and prefrontal cortex of the rat.
The extracellular concentration of dopamine in the striatum and medial prefrontal cortex of the rat was determined following the… 
1991
1991
Electrophilic gamma-lactone kappa-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers.
Benzomorphans with an electrophilic group in the nitrogen substituent were prepared as potentially irreversible ligands for the… 
1985
1985
The opioid receptors in the hamster vas deferens are of the delta-type.
The motor responses of the isolated vas deferens of the hamster were unaffected by opioid-receptor agonists which are selective… 
1978
1978
Benzomorphans. Structure of a position isomer.
May's benzomorphan synthesis leads not only to the alpha or cis isomer and the beta or trans isomer but also to a position isomer… 
1977
1977
Application of the Free-Wilson technique to structurally related series of homologues. Quantitative structure-activity relationship studies of narcotic analgetics.
A series of benzomorphans with ED50 values determined in vivo by the hot-plate method in mice is analyzed by the modified Free… 
1975
1975
Synthesis and analgesic activities of 2,5-dimethyl-2'-hydroxy-9alpha- and -beta-propyl-6,7-benzomorphans.
The 2,5-dimethyl-2'-hydroxy-9alpha- and-beta-propyl-6,7-benzomorphans were synthesized from 4-methyl-3-propylpyridine in five… 
1975
1975
Analgetic activity and in vitro binding constants of some N-alkyl-3-benzazocines.
A homologous series of 3-alkyl-1,2,3,4,5,6-hexahydro-8-hydroxy-6-methyl-3-benzazocines (2) has been synthesized. Analgetic… 
1967
1967
Benzomorphans. Optically Active and trans Isomers.
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