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We predict regulatory targets of vertebrate microRNAs (miRNAs) by identifying mRNAs with conserved complementarity to the seed… Expand The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce… Expand Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public… Expand We describe here a general Amber force field (GAFF) for organic molecules. GAFF is designed to be compatible with existing Amber… Expand The increase in the number of large data sets and the complexity of current probabilistic sequence evolution models necessitates… Expand The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer… Expand A thermostable DNA polymerase was used in an in vitro DNA amplification procedure, the polymerase chain reaction. The enzyme… Expand We describe the production of new alleles of the LEU2, URA3 and TRP1 genes of Saccharomyces cerevisiae by in vitro mutagenesis… Expand Spacer-length (sl) variation in ribosomal RNA gene clusters (rDNA) was surveyed in 502 individual barley plants, including… Expand A method is presented for the rapid isolation of high molecular weight plant DNA (50,000 base pairs or more in length) which is… Expand