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Barbiturates

Known as: Barbiturate, Barbiturates [Chemical/Ingredient] 
A class of drugs characterized as central nervous system (CNS) depressants. Barbiturate compounds bind to the gamma amino butyric acid (GABA)-A… 
National Institutes of Health

Related topics

Related topics

49 relations

Narrower (27)

1,3-dimethylbarbituric acid1-methyl barbituric acid2-hydroxylamino-5-ethyl-5-propylbarbituric acid5-allyl-5-isopropyl-1-methylbarbituric acid
Anesthetics, IntravenousBARBITURATES TESTED FOR:PRID:PT:UR:NOM:SCREENBarbiturates:MCnc:Pt:Meconium:QnBarbiturates:MCnc:Pt:Urine:Qn:Confirm

Broader (5)

Central Nervous System DepressantsGeneral anesthetic drugsPharmaceutical PreparationsPyrimidines

Papers overview

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1986
1986
A collaborative study to investigate the retention reproducibility of barbiturates in HPLC with a view to establishing retention databases for drug identification.
A collaborative study among 10 laboratories has been undertaken to investigate the interlaboratory reproducibility of retention… 
Highly Cited
1980
Highly Cited
1980
Autoradiographic method for measuring the ischemic myocardium at risk: effects of verapamil on infarct size aftr experimental coronary artery occlusion.
Investigation of the efficacy of pharmacologic agents affecting myocardial infarct size after coronary artery occlusion is… 
1979
1979
Correlation of biological activity and high-pressure liquid chromatographic retention index for a series of propranolol, barbiturate, and anthranilic acid analogues.
The antiarrhythmic activity of propranolol analogues, the inotropic activity of propranolol analogues, the anti-inflammatory… 
1976
1976
Inclusion complexation of barbiturates with beta-cyclodextrin in aqueous solution. I. Spectroscopic study on the mode of interaction.
Inclusion complexation of various barbituric and thiobarbituric acid derivatives with β-cyclodextrin in aqueous solution was… 
1974
1974
Abnormal Drug Metabolism after Barbiturate and Paracetamol Overdose
Drug-metabolizing capacity has been assessed by serial measurements of the plasma antipyrine half life in 11 patients with severe… 
1969
1969
Simultaneous spectrophotometric determination of diphenylhydantoin and phenobarbital in biologic specimens.
A rapid,accuratemethodfor determiningdiphenylhydantoin and phenobarbital in a singlebiologicsampleis described.Separationof the… 
Highly Cited
1968
Highly Cited
1968
Evaluation, control, and prediction of drug diffusion through polymeric membranes. 3. Diffusion of barbiturates, phenylalkylamines, dextromethorphan, progesterone, and other drugs.
Silastic membrane demonstrated the greatest permeability among the nine polymeric films studied. The apparent diffusion constants… 
Highly Cited
1967
Highly Cited
1967
Accidental profound hypothermia and barbiturate intoxication. A report of rapid "core" rewarming by peritoneal dialysis.
In a case of profound hypothermia, peritoneal dialysis was utilized with a dual purpose, removing barbiturate and rewarming the… 
Highly Cited
1955
Highly Cited
1955
The effect of a barbiturate and paraldehyde on aqueous humor dynamics in rabbits.
In a previous study from this laboratory, Kornbluth and Linner 1 demonstrated the possibility and utility of tonography in… 
1942
1942
CONVULSIONS IN NONEPILEPTIC PATIENTS ON WITHDRAWAL OF BARBITURATES, ALCOHOL AND OTHER DRUGS
Convulsions in nonepileptic persons after sudden withdrawal of hypnotic drugs are relatively unknown. Experience with 7 patients…