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Individualization of phenytoin dosage regimens
Two methods for arriving at optimum, individual phenytoin dosage regimens have been evaluated in 12 patients. (1) Individual Michaelis‐Menten pharmacokinetic parameters for phenytoin were estimatedExpand
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Cocaine and benzoylecgonine excretion in humans.
Maximal urinary excretion of unchanged cocaine occurred within 2 h of the intranasal absorption of 1.5 mg/kg body weight of cocaine hydrochloride, and diminished rapidly thereafter. Excretion ofExpand
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Enkephalinase inhibition: regulation of ethanol intake in genetically predisposed mice.
This is the first report of alteration in alcohol intake in mice with a genetic predisposition to alcohol preference and known to have innate brain enkephalin deficiencies. We have been able toExpand
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Assay of fluconazole by high-performance liquid chromatography with a mixed-phase column.
A mixed-phase liquid chromatographic column was used to assay fluconazole in plasma, serum, and cerebrospinal fluid. The assay was linear from 0.2 to 20 micrograms/ml, with an average coefficient ofExpand
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Naloxone-induced inhibition of ethanol dependence in mice
IT has been suggested that tetrahydroisoquinoline (TIQ) alkaloids formed in vivo after ethanol ingestion represent metabolic sequelae linking the types of addiction caused by ethanol and theExpand
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12. – ALCOHOL AND OPIATES: A REVIEW OF COMMON NEUROCHEMICAL AND BEHAVIORAL MECHANISMS
Kenneth Blum, Murray G. Hamilton and J.E. Wallace The University of Texas Health Science Center at San Antonio, Departments of Pharmacology and Pathology, San Antonio, Texas, 78284, and TheExpand
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Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection.
A megabore column gas-liquid chromatographic method which uses nitrogen-phosphorus detection was developed for the analysis of fluconazole in plasma, serum, cerebrospinal fluid, or urine. The assayExpand
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A possible relationship between the pineal gland and ethanol preference in the rat.
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Effect of the pineal gland on alcohol consumption by congenitally blind male rats.
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Regional brain [Met]-enkephalin in alcohol-preferring and non-alcohol-preferring inbred strains of mice
Scrutiny of the data from these studies reveals that the C58/J alcohol-preferring mice have significantly lower baseline methionine-enkephalin levels in both the corpus striatum and hypothalamusExpand
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