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BTG2 gene

Known as: PC3, MGC126063, MGC126064 
This gene is involved in the regulation of the G1/S transition of the cell cycle.
National Institutes of Health

Related topics

Related topics

7 relations
BTG1 geneBTG2 protein, humanCell Cycle ControlChronic Lymphocytic Leukemia

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BTG2 wt Allele

Papers overview

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2013
2013
Regulation of Btg2(/TIS21/PC3) expression via reactive oxygen species-protein kinase C-ΝFκΒ pathway under stress conditions.
2012
2012
Tis21 Knock-Out Enhances the Frequency of Medulloblastoma in Patched1 Heterozygous Mice by Inhibiting the Cxcl3-Dependent Migration of Cerebellar Neurons
A failure in the control of proliferation of cerebellar granule neuron precursor cells (GCPs), located in the external granular… 
Highly Cited
2010
Highly Cited
2010
Impact of BTG2 expression on proliferation and invasion of gastric cancer cells in vitro
BTG2 (B cell translocation gene 2) is downregulated in several human tumors and has been known as a tumor suppressor in… 
Highly Cited
2005
Highly Cited
2005
Phosphorylation of Serine 147 of tis21/BTG2/pc3 by p-Erk1/2 Induces Pin-1 Binding in Cytoplasm and Cell Death*
Treatment of U937 cells with epidermal growth factor (EGF) induces phosphorylation of tis21 and subsequent interaction of tis21… 
Highly Cited
2004
Highly Cited
2004
TIS21/BTG2/PC3 is expressed through PKC-delta pathway and inhibits binding of cyclin B1-Cdc2 and its activity, independent of p53 expression.
2003
2003
PICK1, an Anchoring Protein That Specifically Targets Protein Kinase Cα to Mitochondria Selectively upon Serum Stimulation in NIH 3T3 Cells*
PICK1 binds to protein kinase Cα (PKCα) through the carboxylate-binding loop in its PDZ (PSD95/Disc-large/ZO-1) domain and the C… 
Highly Cited
1999
Highly Cited
1999
Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies single neuroepithelial cells that switch from proliferative to neuron-generating division.
At the onset of mammalian neurogenesis, neuroepithelial (NE) cells switch from proliferative to neuron-generating divisions… 
Highly Cited
1998
Highly Cited
1998
Induction of growth inhibition of 293 cells by downregulation of the cyclin E and cyclin‐dependent kinase 4 proteins due to overexpression of TIS21
We earlier reported that TIS21 mRNA expression was markedly decreased in A549 and NCIH69 human lung cancer cells and in thymic… 
Highly Cited
1996
Highly Cited
1996
The Mammalian Immediate-early TIS21 Protein and the Leukemia-associated BTG1 Protein Interact with a Protein-arginine N-Methyltransferase*
The TIS21 immediate-early gene and leukemia-associated BTG1 gene encode proteins with similar sequences. Two-hybrid analysis… 
Highly Cited
1991
Highly Cited
1991
Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters.
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