BRL-38227

The airways relaxant effects and mechanism of action of the potassium channel activators BRL 38227 and pinacidil have been… Expand

BACKGROUND Potassium (K+) channel activators, such as cromakalim, open ATP sensitive K+ channels and relax airway smooth muscle… Expand

SummaryPotassium (K+) channel openers decrease intracellular free Ca2+ concentrations ([Ca2+]i) by hyperpolarizing the membrane… Expand

1. Smooth muscle cells of the rat portal vein were dispersed by enzymatic treatment and recordings of whole-cell membrane… Expand

1. The contractile and electrical responses to acetylcholine (ACh) in isolated segments of guinea-pig and rabbit coronary… Expand

1. Single smooth muscle cells were isolated from the rabbit portal vein and the human mesenteric artery and whole cell currents… Expand

1. Single neuronal cells were freshly isolated from the ventromedial hypothalamic nuclei (VMHN) of the rat brain. Currents… Expand

The effects of BRL 38227 and glibenclamide on intracellular calcium stores were investigated in permeabilized cultured airway… Expand

1. Conscious, Long Evans rats, chronically instrumented for the measurement of regional haemodynamics, were used to assess… Expand

Potassium (K+) channels are present on airway smooth muscle cells, and their activation results in hyperpolarization and… Expand