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Cromakalim

Known as: 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, trans-(+-)-, Cromakalim [Chemical/Ingredient] 
A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma… 
National Institutes of Health

Related topics

Related topics

18 relations

Broader (6)

Antihypertensive AgentsBenzopyransBronchodilator AgentsParasympatholytics

Narrower (5)

BRL-34915BRL-38226BRL-38227Lemakalim
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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2001
2001
Elcatonin-mediated contractile and relaxant responses in SHR femoral artery.
AIM To study the effect of repeated systemic injections of elcatonin (a synthetic analog of eel calcitonin) on the responses of… 
1999
1999
Differential effects of lidocaine and mexiletine on relaxations to ATP-sensitive K+ channel openers in rat aortas.
BACKGROUND In cardiac myocytes, lidocaine reduces but mexiletine increases adenosine triphosphate (ATP)-sensitive K+ currents… 
1999
1999
Attenuation of basilar artery spasm after experimental subarachnoid hemorrhage in rabbit by potassium channel activator cromakalim--a preliminary result.
Cerebral vasospasm associated with aneurysmal subarachnoid hemorrhage (SAH) remains a major complication in patients suffering… 
1999
1999
Voltage sensitivity of slow wave frequency in isolated circular muscle strips from guinea pig gastric antrum
Huang, S.-M., S. Nakayama, S. Iino, and T. Tomita. Voltage sensitivity of slow wave frequency in isolated circular muscle strips… 
1993
1993
Electrophysiologic and Arrhythmogenic Effects of the Potassium Channel Agonist BRL 38227 in Anesthetized Dogs
Although potassium channel openers have been demonstrated to induce arterial vasodilation and shortening of the QT interval, the… 
1993
1993
Properties of diazoxide and cromakalim‐induced activation of potassium channels in cultured rat and RINm5F insulin‐secreting cells; effects of GTP
Experiments have been carried out to examine the effects of GTP on the opening of K+ channels in insulin‐secreting cells by… 
1993
1993
In Vivo Cardiac Electrophysiologic Effects of RWJ 29009, a New Potassium‐Channel Activator, in Comparison to Cromakalim and Nicardipine
RWJ 29009 is a new potassium channel activator with prominent coronary and peripheral vasodilating actions. Because of the… 
1993
1993
Functional Study on the Effects of Nifedipine, Cromakalim, and the Absence of Extracellular Ca2+ on α1 -Adrenoceptor‐Mediated Excitation‐Contraction Coupling in Isolated Rat Portal Vein: Comparison…
The effects of Ca2+-entry blockade by nifedipine, K+ channel opening by cromakalim, and of omitting extracellular Ca2+ on the… 
1993
1993
Effect of KRN2391 on Venous Return: Comparison with Other Vasodilators
We compared the cardiohemodynamic effects of KRN2391, a novel coronary vasodilator, with those of nicorandil, nifedipine… 
1992
1992
Inhibition in the rat of nitric oxide synthesis in vivo does not attenuate the hypotensive action of acetylcholine, ATP or bradykinin
The hypotensive action of acetylcholine in vivo may be dependent on the release of the novel vasorelaxant, endothelium‐derived…