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Cromakalim

Known as: 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, trans-(+-)-, Cromakalim [Chemical/Ingredient] 
A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2002
Review
2002
  • J. Brayden
  • Clinical and experimental pharmacology…
  • 2002
  • Corpus ID: 43138205
1. ATP‐sensitive potassium channels (KATP) are present in vascular smooth muscle cells and play important roles in the vascular… Expand
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Highly Cited
1998
Highly Cited
1998
Discovered in the cardiac sarcolemma, ATP-sensitive K+(KATP) channels have more recently also been identified within the inner… Expand
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Highly Cited
1997
Highly Cited
1997
Previous studies showed a poor correlation between sarcolemmal K+ currents and cardioprotection for ATP-sensitive K+ channel… Expand
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Highly Cited
1997
Highly Cited
1997
Apoptosis of mouse neocortical neurons induced by serum deprivation or by staurosporine was associated with an early enhancement… Expand
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Highly Cited
1996
Highly Cited
1996
We have cloned an isoform of the sulfonylurea receptor (SUR), designated SUR2. Coexpression of SUR2 and the inward rectifier K… Expand
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Highly Cited
1996
Highly Cited
1996
The biochemical properties of the mitochondrial K channel are very similar to those of plasma membrane K channels, including… Expand
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Highly Cited
1995
Highly Cited
1995
Summary: We endeavored to determine if the enhanced shortening of the myocardial action potential duration (APD) during ischemia… Expand
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Highly Cited
1994
Highly Cited
1994
We have analyzed the biophysical and pharmacological properties of five cloned K+ (Kv) channels (Kv1.1, Kv1.2, Kv1.3, Kv1.5, and… Expand
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Highly Cited
1990
Highly Cited
1990
The function of the heart depends critically on an adequate oxygen supply through the coronary arteries. Coronary arteries dilate… Expand
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Highly Cited
1989
Highly Cited
1989
Vasodilators are used clinically for the treatment of hypertension and heart failure. The effects of some vasodilators seem to be… Expand
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