Cromakalim

Known as: 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, trans-(+-)-, Cromakalim [Chemical/Ingredient] 
A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma… (More)
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Ischemic and pharmacological preconditioning can be triggered by an intracellular signaling pathway in which Gi-coupled surface… (More)
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Highly Cited
1998
Highly Cited
1998
Discovered in the cardiac sarcolemma, ATP-sensitive K+(KATP) channels have more recently also been identified within the inner… (More)
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Highly Cited
1997
Highly Cited
1997
Apoptosis of mouse neocortical neurons induced by serum deprivation or by staurosporine was associated with an early enhancement… (More)
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Highly Cited
1996
Highly Cited
1996
The biochemical properties of the mitochondrial KATP channel are very similar to those of plasma membrane KATP channels… (More)
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Highly Cited
1994
Highly Cited
1994
We have analyzed the biophysical and pharmacological properties of five cloned K+ (Kv) channels (Kv1.1, Kv1.2, Kv1.3, Kv1.5, and… (More)
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Highly Cited
1991
Highly Cited
1991
The potassium channel activators cromakalim and pinacidil were recently shown to have anti-ischemic properties in isolated… (More)
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Highly Cited
1990
Highly Cited
1990
The function of the heart depends critically on an adequate oxygen supply through the coronary arteries. Coronary arteries dilate… (More)
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Highly Cited
1989
Highly Cited
1989
Vasodilators are used clinically for the treatment of hypertension and heart failure. The effects of some vasodilators seem to be… (More)
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Highly Cited
1989
Highly Cited
1989
The direct cardioprotective efficacy of the potassium channel activators pinacidil and cromakalim was determined in isolated… (More)
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Highly Cited
1988
Highly Cited
1988
In cardiac myocytes, cromakalim (BRL 34915), a potassium channel opener, activates a time-independent K+ current exhibiting poor… (More)
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