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BPDZ-73

Known as: BPDZ 73 
National Institutes of Health

Papers overview

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2008
2008
New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.
2006
2006
Selective pancreatic ATP-sensitive potassium channel openers for the treatment of glucose homeostasis disorders
Disorders of glucose homeostasis may be associated with severe pathologies such as type 1 and type 2 diabetes, insulinoma… 
2005
2005
Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium…
2005
2005
Effect on K(ATP) channel activation properties and tissue selectivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides.
The present work explored 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides diversely substituted in the 7-position. Those… 
2002
2002
2-Alkyl-3-Alkylamino-2H-Benzo- and Pyridothiadiazine 1,1-Dioxides: From K+ATP Channel Openers to Ca++ Channel Blockers?
Abstract A series of 2-alkyl-3-alkylamino-2Hbenzo and 2-alkyl-3-alkylamino-2Hpyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides… 
2000
2000
A potent diazoxide analogue activating ATP-sensitive K+ channels and inhibiting insulin release
Aims/hypothesis. To characterise the effects of BPDZ 73 (7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide), a… 
2000
2000
Preparation and biological evaluation of new 7-substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides, analogues of the KATP channel opener BPDZ 73
2000
2000
Synthesis and biological evaluation of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides as KATP channel openers structurally related to BPDZ 73
2000
2000
New 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides related to BPDZ 73 as putative KATP channel openers: design, synthesis and pharmacological evaluation
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