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Improved methodology for the detection and quantification of the acrosome reaction in mouse spermatozoa.
TLDR
Ionophore challenge confirmed the existence of a calcium-dependent acrosome reaction in mouse spermatozoa and validated the use of PNA-FITC to quantify this physiological process. Expand
Ca2+ entry through L-type voltage-sensitive Ca2+ channels stimulates the release of human chorionic gonadotrophin and placental lactogen by placental explants.
TLDR
The data clearly show that a rise in [K+]o stimulates the release of hCG and hPL from placental explants, and these secretory effects can be viewed as resulting from a Ca2+ entry through voltage-sensitive Ca1+ channels of the L-type. Expand
Hydroxylamine, a nitric oxide donor, inhibits insulin release and activates K+ATP channels.
TLDR
Experimental results suggest that the negative insulinotropic action of the NO donor results, at least in part, from the activation of ATP-sensitive K+ channels leading to a decrease in Ca2+ influx and [Ca2+]i. Expand
Blockade of calcium entry in smooth muscle cells by the antidepressant imipramine.
TLDR
Findings suggest that the myorelaxant properties of imipramine, and probably also setraline and mianserin, could result from their capacity to inhibit the voltage-sensitive Ca2+ channels. Expand
The riddle of formycin A insulinotropic action.
TLDR
The view that formycin A exerts any major effect upon intracellular Ca2+ redistribution, protein kinase C activity, or cyclic AMP net production met with objections. Expand
Synergistic effect of a tumor-promoting phorbol ester and a hypoglycemic sulfonylurea upon insulin release.
TLDR
The facilitation by TPA of gliclazide-induced insulin release suggests that a biophysical interference with the handling of cations at the plasma membrane level represents the primary site of action of hypoglycemic sulfonylureas in the pancreatic B cell. Expand
Stimulus-secretion coupling of arginine-induced insulin release. Insulinotropic action of agmatine.
TLDR
The insulinotropic action of agmatine is compatible with the view that endogenously formed polyamines may play a role in the secretory response of islet cells to L-arginine. Expand
Contractile effects of substance P and other tachykinins on the mouse isolated distal colon
TLDR
Experimental findings indirectly support the assumption that the mouse distal colon could possess different tachykinin‐binding sites and suggest that the myogenic effects of SP and physalaemin are mainly dependent on their ability to promote Ca2+ influx. Expand
Effects of the calcium channel agonist, BAY K 8644, on electrical activity in mouse pancreatic B-cells.
TLDR
The existence of a Ca2+-induced Ca2-channel inactivation process in the pancreatic B-cell is proposed, and the results suggest that BAY K 8644 acts on the open Ca2+, at a membrane potential of -50 mV. Expand
Sodium nitroprusside inhibits glucose-induced insulin release by activating ATP-sensitive K+ channels.
TLDR
The experimental results suggest that cGMP potentiates glucose-induced insulin release without affecting ionic movements, and sodium nitroprusside appears to be an inadequate pharmacological tool to characterize the involvement of cG MP in the insulin secretory process. Expand
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