Selective pancreatic ATP-sensitive potassium channel openers for the treatment of glucose homeostasis disorders

@article{Tullio2006SelectivePA,
  title={Selective pancreatic ATP-sensitive potassium channel openers for the treatment of glucose homeostasis disorders},
  author={Pascal de Tullio and Philippe Lebrun and Xavier Florence and M. H. Antoine and Pierre Francotte and Bernard Pirotte},
  journal={Drugs of The Future},
  year={2006},
  volume={31},
  pages={991-1001}
}
Disorders of glucose homeostasis may be associated with severe pathologies such as type 1 and type 2 diabetes, insulinoma, persistent hyperinsulinemic hypoglycemia of infancy (PHHI), polycystic ovary syndrome (PCOS) and/or obesity. Specific activation of the Kir6.2/SUR1 K ATP channel subtype has been shown to be beneficial for the treatment of these pathologies. Starting from diazoxide, a nonselective Kir6.2/SUR1 K ATP channel activator, many research groups have conducted searches in an… Expand
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