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BOF 4272
Known as:
BOF-4272
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Enzyme Inhibitors
Triazines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Xanthine oxidase inhibitors suppress testicular germ cell apoptosis induced by experimental cryptorchidism.
A. Kumagai
,
H. Kodama
,
+5 authors
Toshinobu Tanaka
Molecular human reproduction
2002
Corpus ID: 32887203
Apoptotic degeneration of germ cells in cryptorchid testis is associated with an increased level of reactive oxygen species, and…
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2001
2001
Enantioselective uptake of BOF-4272, a xanthine oxidase inhibitor with a chiral sulfoxide, by isolated rat hepatocytes.
S. Naito
,
M. Nishimura
Yakugaku zasshi : Journal of the Pharmaceutical…
2001
Corpus ID: 25274759
The transport mechanisms of the enantiomers of BOF-4272, a new drug for the treatment of hyperuricemia, were studied using…
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2000
2000
Evaluation of the Pharmacological Actions and Pharmacokinetics of BOF‐4272, a Xanthine Oxidase Inhibitor, in Mouse Liver
S. Naito
,
M. Nishimura
,
Y. Tamao
The Journal of pharmacy and pharmacology
2000
Corpus ID: 21394574
BOF‐4272 (±)‐8‐(3‐methoxy‐4‐phenylsulphinylphenyl) pyrazolo[1,5‐a]‐1,3,5‐triazine‐4‐(1H)‐one, a new synthetic anti‐hyperuricaemic…
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1997
1997
Influence of albumin on enantioselective local disposition of BOF-4272, a xanthine oxidase inhibitor with chiral sulfoxide, in rat liver.
M. Nishimura
,
K. Yamaoka
,
S. Naito
,
T. Nakagawa
Biological and Pharmaceutical Bulletin
1997
Corpus ID: 2311206
8-(3-Methoxy-4-phenylsulfinylphenyl) pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one (BOF-4272) blocks xanthine oxidase/xanthine…
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1996
1996
Hepatic local disposition of a drug with high protein binding and high hepatic clearance using BOF-4272 as a model drug.
M. Nishimura
,
K. Yamaoka
,
S. Naito
,
T. Nakagawa
Biological and Pharmaceutical Bulletin
1996
Corpus ID: 32578628
The local disposition of a drug, which is efficiently eliminated by the liver in spite of very high binding with serum albumin…
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1995
1995
Effect of temperature in perfusate on local hepatic disposition of BOF-4272, a new xanthine oxidase inhibitor.
M. Nishimura
,
K. Yamaoka
,
H. Yasui
,
S. Naito
,
T. Nakagawa
Biological and Pharmaceutical Bulletin
1995
Corpus ID: 38692213
The effect of temperature on the local hepatic disposition of BOF-4272 [(+/-)-8-(3-methoxy-4-phenylsulfinyl-phenyl)pyrazolo[1,5-a…
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Highly Cited
1995
Highly Cited
1995
Mechanism of Inhibition of Xanthine Oxidase with a New Tight Binding Inhibitor (*)
K. Okamoto
,
T. Nishino
Journal of Biological Chemistry
1995
Corpus ID: 39359250
The mechanism of inhibition of milk xanthine oxidase and xanthine dehydrogenase by the tight binding inhibitor, sodium-8-(3…
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1994
1994
Characteristic properties of retinal oxidase (retinoic acid synthase) from rabbit hepatocytes.
M. Tsujita
,
S. Tomita
,
S. Miura
,
Y. Ichikawa
Biochimica et Biophysica Acta
1994
Corpus ID: 40884323
1994
1994
Pharmacokinetic and pharmacodynamic properties of a novel xanthine oxidase inhibitor, BOF-4272, in healthy volunteers.
T. Uematsu
,
M. Nakashima
Journal of Pharmacology and Experimental…
1994
Corpus ID: 19857757
A novel pyrazolotriazine derivative [BOF-4272, sodium-(+-)-8-(3-methoxy-4-phenylsulfinylphenyl)pyrazolo[1,5-a]-1 ,3,5-triazine-4…
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1991
1991
A novel xanthine dehydrogenase inhibitor (BOF-4272).
S. Sato
,
K. Tatsumi
,
T. Nishino
Advances in Experimental Medicine and Biology
1991
Corpus ID: 43269788
An inhibitor of xanthine oxidase (XO)/xanthine dehydrogenase (XDH), an enzyme catalyzing the last step of purine catabolism…
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