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BOF 4272

Known as: BOF-4272 
National Institutes of Health

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2 relations

Broader (2)

Enzyme InhibitorsTriazines

Papers overview

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2002
2002
Stereoselective pharmacokinetics of BOF-4272 racemate after oral administration to rats and dogs.
The stereoselective pharmacokinetics of BOF-4272 enantiomers in rats and dogs was investigated by simultaneously measuring… 
2002
2002
In vitro and in vivo studies on the stereoselective pharmacokinetics and biotransformation of an (S)-(–)- and (R)-(+)-pyrazolotriazine sulfoxide in the male rat
1. BOF-4272 (a pyrazolotriazine sulfoxide) is a new drug for the treatment of hyperuricemia. The pharmacokinetics and… 
2001
2001
Enantioselective uptake of BOF-4272, a xanthine oxidase inhibitor with a chiral sulfoxide, by isolated rat hepatocytes.
The transport mechanisms of the enantiomers of BOF-4272, a new drug for the treatment of hyperuricemia, were studied using… 
2001
2001
Enantioselective Uptake of BOF-4272, a Xanthine Oxidase Inhibitor with a Chiral Sulfoxide, by Isolated Rat Hepatocytes
1999
1999
Metabolic pathways and pharmacokinetics of BOF-4272, a sulfoxide-containing drug, in the dog: in vivo and in vitro studies.
BOF-4272, (+/-)-8-(3-methoxy-4- phenylsulfinylphenyl)pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one, is a new drug intended for the… 
1999
1999
Biotransformation of BOF-4272, a sulfoxide-containing drug, in the cynomolgus monkey
SummaryBOF-4272, (±)-8-(3-methoxy-4-phenylsulfinylphenyl) pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one), is a new drug intended for… 
1996
1996
Hepatic local disposition of a drug with high protein binding and high hepatic clearance using BOF-4272 as a model drug.
The local disposition of a drug, which is efficiently eliminated by the liver in spite of very high binding with serum albumin… 
1995
1995
Effect of temperature in perfusate on local hepatic disposition of BOF-4272, a new xanthine oxidase inhibitor.
The effect of temperature on the local hepatic disposition of BOF-4272 [(+/-)-8-(3-methoxy-4-phenylsulfinyl-phenyl)pyrazolo[1,5-a… 
1994
1994
Local disposition of a new xanthine oxidase/xanthine dehydrogenase inhibitor, BOF-4272, in rat liver.
The local hepatic disposition of BOF-4272, a newly developed xanthine oxidase (XO)/xanthine dehydrogenase (XDH) inhibitor, was… 
1993
1993
Effect of BOF-4272 on the oxidation of allopurinol and pyrazinamide in vivo. Is xanthine dehydrogenase or aldehyde oxidase more important in oxidizing both allopurinol and pyrazinamide?
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