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BOF 4272

Known as: BOF-4272 
National Institutes of Health

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2 relations

Broader (2)

Enzyme InhibitorsTriazines

Papers overview

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2003
2003
Xanthine oxidase-catalyzed metabolism of 2-nitrofluorene, a carcinogenic air pollutant, in rat skin.
The reductive metabolism of 2-nitrofluorene, a carcinogenic air pollutant, in rat skin microsomes and cytosol was investigated. 2… 
2002
2002
Stereoselective pharmacokinetics of BOF-4272 racemate after oral administration to rats and dogs.
The stereoselective pharmacokinetics of BOF-4272 enantiomers in rats and dogs was investigated by simultaneously measuring… 
2001
2001
Enantioselective uptake of BOF-4272, a xanthine oxidase inhibitor with a chiral sulfoxide, by isolated rat hepatocytes.
The transport mechanisms of the enantiomers of BOF-4272, a new drug for the treatment of hyperuricemia, were studied using… 
1999
1999
Metabolic pathways and pharmacokinetics of BOF-4272, a sulfoxide-containing drug, in the dog: in vivo and in vitro studies.
BOF-4272, (+/-)-8-(3-methoxy-4- phenylsulfinylphenyl)pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one, is a new drug intended for the… 
1999
1999
Biotransformation of BOF-4272, a sulfoxide-containing drug, in the cynomolgus monkey
SummaryBOF-4272, (±)-8-(3-methoxy-4-phenylsulfinylphenyl) pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one), is a new drug intended for… 
1997
1997
Leukocyte contribution to parenchymal cell death in an experimental model of inflammation
The relationship between leukocyte migration and parenchymal cell death in vivo remains poorly documented. Accordingly, cell… 
1996
1996
Hepatic local disposition of a drug with high protein binding and high hepatic clearance using BOF-4272 as a model drug.
The local disposition of a drug, which is efficiently eliminated by the liver in spite of very high binding with serum albumin… 
1995
1995
Effect of temperature in perfusate on local hepatic disposition of BOF-4272, a new xanthine oxidase inhibitor.
The effect of temperature on the local hepatic disposition of BOF-4272 [(+/-)-8-(3-methoxy-4-phenylsulfinyl-phenyl)pyrazolo[1,5-a… 
1994
1994
Local disposition of a new xanthine oxidase/xanthine dehydrogenase inhibitor, BOF-4272, in rat liver.
The local hepatic disposition of BOF-4272, a newly developed xanthine oxidase (XO)/xanthine dehydrogenase (XDH) inhibitor, was… 
1993
1993
Effect of BOF-4272 on the oxidation of allopurinol and pyrazinamide in vivo. Is xanthine dehydrogenase or aldehyde oxidase more important in oxidizing both allopurinol and pyrazinamide?
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