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BOF 4272

Known as: BOF-4272 
 
National Institutes of Health

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Related topics

2 relations

Broader (2)

Enzyme InhibitorsTriazines

Papers overview

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Highly Cited
2002
Highly Cited
2002
Xanthine oxidase inhibitors suppress testicular germ cell apoptosis induced by experimental cryptorchidism.
Apoptotic degeneration of germ cells in cryptorchid testis is associated with an increased level of reactive oxygen species, and… Expand
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2001
2001
Enantioselective uptake of BOF-4272, a xanthine oxidase inhibitor with a chiral sulfoxide, by isolated rat hepatocytes.
The transport mechanisms of the enantiomers of BOF-4272, a new drug for the treatment of hyperuricemia, were studied using… Expand
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1997
1997
Influence of albumin on enantioselective local disposition of BOF-4272, a xanthine oxidase inhibitor with chiral sulfoxide, in rat liver.
8-(3-Methoxy-4-phenylsulfinylphenyl) pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one (BOF-4272) blocks xanthine oxidase/xanthine… Expand
1996
1996
Hepatic local disposition of a drug with high protein binding and high hepatic clearance using BOF-4272 as a model drug.
The local disposition of a drug, which is efficiently eliminated by the liver in spite of very high binding with serum albumin… Expand
1995
1995
Study of the enantioselective binding between BOF-4272 and serum albumins by means of high-performance frontal analysis.
High-performance frontal analysis (HPFA) was incorporated in an on-line HPLC system for the study of the enantioselective binding… Expand
Highly Cited
1995
Highly Cited
1995
Mechanism of Inhibition of Xanthine Oxidase with a New Tight Binding Inhibitor (*)
The mechanism of inhibition of milk xanthine oxidase and xanthine dehydrogenase by the tight binding inhibitor, sodium-8-(3… Expand
1994
1994
Pharmacokinetic and pharmacodynamic properties of a novel xanthine oxidase inhibitor, BOF-4272, in healthy volunteers.
A novel pyrazolotriazine derivative [BOF-4272, sodium-(+-)-8-(3-methoxy-4-phenylsulfinylphenyl)pyrazolo[1,5-a]-1 ,3,5-triazine-4… Expand
1994
1994
Local disposition of a new xanthine oxidase/xanthine dehydrogenase inhibitor, BOF-4272, in rat liver.
The local hepatic disposition of BOF-4272, a newly developed xanthine oxidase (XO)/xanthine dehydrogenase (XDH) inhibitor, was… Expand
1993
1993
Effect of BOF-4272 on the oxidation of allopurinol and pyrazinamide in vivo. Is xanthine dehydrogenase or aldehyde oxidase more important in oxidizing both allopurinol and pyrazinamide?
Allopurinol or pyrazinamide was administered to rats treated with BOF-4272 (a potent xanthine oxidase inhibitor) to investigate… Expand
1991
1991
A novel xanthine dehydrogenase inhibitor (BOF-4272).
An inhibitor of xanthine oxidase (XO)/xanthine dehydrogenase (XDH), an enzyme catalyzing the last step of purine catabolism… Expand
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