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BOF 4272

Known as: BOF-4272 
National Institutes of Health

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2 relations

Broader (2)

Enzyme InhibitorsTriazines

Papers overview

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Highly Cited
2002
Highly Cited
2002
Xanthine oxidase inhibitors suppress testicular germ cell apoptosis induced by experimental cryptorchidism.
Apoptotic degeneration of germ cells in cryptorchid testis is associated with an increased level of reactive oxygen species, and… 
2001
2001
Enantioselective uptake of BOF-4272, a xanthine oxidase inhibitor with a chiral sulfoxide, by isolated rat hepatocytes.
The transport mechanisms of the enantiomers of BOF-4272, a new drug for the treatment of hyperuricemia, were studied using… 
2000
2000
Evaluation of the Pharmacological Actions and Pharmacokinetics of BOF‐4272, a Xanthine Oxidase Inhibitor, in Mouse Liver
BOF‐4272 (±)‐8‐(3‐methoxy‐4‐phenylsulphinylphenyl) pyrazolo[1,5‐a]‐1,3,5‐triazine‐4‐(1H)‐one, a new synthetic anti‐hyperuricaemic… 
1997
1997
Influence of albumin on enantioselective local disposition of BOF-4272, a xanthine oxidase inhibitor with chiral sulfoxide, in rat liver.
8-(3-Methoxy-4-phenylsulfinylphenyl) pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one (BOF-4272) blocks xanthine oxidase/xanthine… 
1996
1996
Hepatic local disposition of a drug with high protein binding and high hepatic clearance using BOF-4272 as a model drug.
The local disposition of a drug, which is efficiently eliminated by the liver in spite of very high binding with serum albumin… 
1995
1995
Effect of temperature in perfusate on local hepatic disposition of BOF-4272, a new xanthine oxidase inhibitor.
The effect of temperature on the local hepatic disposition of BOF-4272 [(+/-)-8-(3-methoxy-4-phenylsulfinyl-phenyl)pyrazolo[1,5-a… 
Highly Cited
1995
Highly Cited
1995
Mechanism of Inhibition of Xanthine Oxidase with a New Tight Binding Inhibitor (*)
The mechanism of inhibition of milk xanthine oxidase and xanthine dehydrogenase by the tight binding inhibitor, sodium-8-(3… 
1994
1994
Characteristic properties of retinal oxidase (retinoic acid synthase) from rabbit hepatocytes.
1994
1994
Pharmacokinetic and pharmacodynamic properties of a novel xanthine oxidase inhibitor, BOF-4272, in healthy volunteers.
A novel pyrazolotriazine derivative [BOF-4272, sodium-(+-)-8-(3-methoxy-4-phenylsulfinylphenyl)pyrazolo[1,5-a]-1 ,3,5-triazine-4… 
1991
1991
A novel xanthine dehydrogenase inhibitor (BOF-4272).
An inhibitor of xanthine oxidase (XO)/xanthine dehydrogenase (XDH), an enzyme catalyzing the last step of purine catabolism… 
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