S. Naito

Publications15
h-index7
Citations106
Highly Influential Citations1
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Evaluation of the Pharmacological Actions and Pharmacokinetics of BOF‐4272, a Xanthine Oxidase Inhibitor, in Mouse Liver
BOF‐4272 (±)‐8‐(3‐methoxy‐4‐phenylsulphinylphenyl) pyrazolo[1,5‐a]‐1,3,5‐triazine‐4‐(1H)‐one, a new synthetic anti‐hyperuricaemic drug, which has a chiral centre and exists as racemates, is a potent… Expand
  • 10
  • 1
Study of the enantioselective binding between BOF-4272 and serum albumins by means of high-performance frontal analysis.
High-performance frontal analysis (HPFA) was incorporated in an on-line HPLC system for the study of the enantioselective binding of BOF-4272, a new xanthine oxidase inhibitor, with human, bovine and… Expand
  • 25
Hepatic local disposition of a drug with high protein binding and high hepatic clearance using BOF-4272 as a model drug.
The local disposition of a drug, which is efficiently eliminated by the liver in spite of very high binding with serum albumin, was investigated using BOF-4272 as a model drug in the hepatic… Expand
  • 16
Effect of temperature in perfusate on local hepatic disposition of BOF-4272, a new xanthine oxidase inhibitor.
The effect of temperature on the local hepatic disposition of BOF-4272 [(+/-)-8-(3-methoxy-4-phenylsulfinyl-phenyl)pyrazolo[1,5-a]-1,3,5- triazine-4-olate], a new drug used to treat hyperuricemia,… Expand
  • 11
Influence of albumin on enantioselective local disposition of BOF-4272, a xanthine oxidase inhibitor with chiral sulfoxide, in rat liver.
8-(3-Methoxy-4-phenylsulfinylphenyl) pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one (BOF-4272) blocks xanthine oxidase/xanthine dehydrogenase in the liver. BOF-4272 with a sulfoxide chiral center includes… Expand
  • 8
Local disposition of a new xanthine oxidase/xanthine dehydrogenase inhibitor, BOF-4272, in rat liver.
The local hepatic disposition of BOF-4272, a newly developed xanthine oxidase (XO)/xanthine dehydrogenase (XDH) inhibitor, was evaluated in the rat perfusion system following pulse input of the drug… Expand
  • 8
Studies on Metabolic Fate of Oxybutynin Hydrochloride (3) Metabolism in Human and Dog and The Site of Biotransfornation and the Effect on Enzymes Induction in the Rats
The metabolites, metabolizing organs of oxybutynin and its effect on the induction of drug metabolizing enzymes were investigated in rat, dog and human after oral administrations of oxybutynin and… Expand
  • 2
Pharmacokinetics of BOF‐4272, a Xanthine Oxidase Inhibitor, after Single Intravenous or Oral Administration to Male Mice and Rats
BOF‐4272, (±)‐8‐(3‐methoxy‐4‐phenylsulphinylphenyl) pyrazolo [1,5‐a]‐1,3,5‐triazine‐4 (1H)‐one), is a new drug intended for the treatment of hyperuricaemia. This report describes the detailed… Expand
  • 5
Metabolic pathways and pharmacokinetics of BOF-4272, a sulfoxide-containing drug, in the dog: in vivo and in vitro studies.
BOF-4272, (+/-)-8-(3-methoxy-4- phenylsulfinylphenyl)pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one, is a new drug intended for the treatment of hyperuricemia. This report describes the detailed metabolic… Expand
  • 6
Enantioselective uptake of BOF-4272, a xanthine oxidase inhibitor with a chiral sulfoxide, by isolated rat hepatocytes.
  • S. Naito, M. Nishimura
  • Chemistry, Medicine
  • Yakugaku zasshi : Journal of the Pharmaceutical…
  • 1 December 2001
The transport mechanisms of the enantiomers of BOF-4272, a new drug for the treatment of hyperuricemia, were studied using freshly prepared rat hepatocytes. BOF-4272 consists of S(-) and R(+)… Expand
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