• Publications
  • Influence
Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis
TLDR
It is proposed that different degrees of direct mesothelial injury by thin and thick MWCNTs are responsible for the extent of inflammogenicity and carcinogenicity, and suggested that control of the diameter of M WCNTs could reduce the potential hazard to human health.
Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice.
TLDR
It is demonstrated that chronic overexpression of eNOS does not inhibit, but accelerates, atherosclerosis under hypercholesterolemia and that eNos dysfunction appears to play important roles in the progression of Atherosclerosis in apoE-KO/eNOS-Tg mice.
Possible involvement of singlet oxygen species as multiple oxidants in p450 catalytic reactions.
TLDR
The studies that have been conducted on the detection and characterization of ROS in P450 reactions related to drug metabolism that involve the possibility of 1O2 in the P450 catalytic cycle are described.
Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure.
TLDR
More potent derivatives 33 with 2,5-difluorophenyl and 50 with a benzophenone in place of the phenyl group are developed, which could be a valuable second-generation derivative with both vascular disrupting and cytotoxic activities.
A new halogenated antidiabetic vanadyl complex, bis(5-iodopicolinato)oxovanadium(IV): in vitro and in vivo insulinomimetic evaluations and metallokinetic analysis
TLDR
VO(IPA)2 is indicated to be a preferred agent to treat insulin-dependent diabetes mellitus in experimental animals on the basis of the insulinomimetic action and the organ distribution of vanadium and the blood disposition of vanadyl species.
Generation and distribution of reactive oxygen species in the skin of hairless mice under UVA: studies on in vivo chemiluminescent detection and tape stripping methods
TLDR
It is concluded that ROS induced by UVA exposure occurs and distributes in the outermost layer of the stratum corneum.
Visualization and characterization of UVB-induced reactive oxygen species in a human skin equivalent model
TLDR
This model is useful for not only visualizing the production of UVB-induced ROS in real-time but also evaluating the efficacy of topically applied anti-oxidative compounds to suppress ROS generation and attenuate sequential chemical and biological responses.
...
...