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BLNK wt Allele

Known as: B-Cell Linker wt Allele, BLNK, SLP65 
Human BLNK wild-type allele is located within 10q23.2-q23.33 and is approximately 80 kb in length. This allele, which encodes B-cell linker protein… 
National Institutes of Health

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10q23.2-q23.33B Cell Receptor Signaling PathwayB cell linker proteinB-cell childhood acute lymphoblastic leukemia

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Are Patients with X-Linked Agammaglobulinemia at Increased Risk of Developing Acute Lymphoblastic Leukemia?
In the current issue of Journal of Clinical Immunology, Hoshino et al. describe a patient with X-linked agammaglob-ulinemia (XLA… 
2007
2007
Genomics: Global views of leukaemia
Genomic characterization of a type of leukaemia has resulted in the identification of common genetic abnormalities that underlie… 
2006
2006
SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells
Perpetual V(D)J recombinase activity involving multiple DNA double-strand break events in B-cell lineage leukemia and lymphoma… 
2006
2006
The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells
SLP65 represents a critical component in (pre-) B cell receptor signal transduction but is compromised in a subset of pre-B cell… 
2005
2005
Expression pattern of intracellular leukocyte-associated proteins in primary mediastinal B cell lymphoma
Two microarray studies of mediastinal B cell lymphoma have shown that this disease has a distinct gene expression profile, and… 
2004
2004
Identification and Characterization of a Novel BASH N Terminus-associated Protein, BNAS2*
A B cell-specific adaptor protein, BASH (also known as BLNK or SLP-65), is crucial for B cell receptor (BCR) signaling. BASH… 
2004
2004
Macrophage activation and Fcγ receptor‐mediated signaling do not require expression of the SLP‐76 and SLP‐65 adaptors
The Src‐homology 2 domain‐containing, leukocyte‐specific phosphoprotein of 76 kDa (SLP‐76) is a hematopoietic adaptor that plays… 
2004
2004
The BCR-ABL 1 Kinase Bypasses Selection for the Expression of a Pre – B Cell Receptor in Pre – B Acute Lymphoblastic Leukemia Cells
The BCR-ABL1 kinase expressed in acute lymphoblastic leukemia (ALL) drives malignant transformation of human pre–B cells… 
2001
2001
Role of BLNK in oxidative stress signaling in B cells.
BLNK (B cell linker protein) represents a central linker protein that bridges the B cell receptor-associated kinases with a… 
2000
2000
Functional Complementation of BLNK by SLP-76 and LAT Linker Proteins*
Recent studies have demonstrated a requirement for the SLP-76 (SH2 domain-containingleukocyte protein of 76 kDa) and LAT (linker… 
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