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B cell linker protein
Known as:
BLNK
, B-Cell Linker Protein
, B-Cell Linker
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B-Cell Linker, encoded by the BLNK gene, is essential for normal B-cell development. This protein interfaces the B-cell receptor-associated SYK…
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National Institutes of Health
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Related topics
Related topics
13 relations
Broader (1)
Adaptor Proteins, Signal Transducing
Adaptor Signaling Protein Gene
B Cell Receptor Signaling Pathway
B-cell childhood acute lymphoblastic leukemia
BLNK gene
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Narrower (2)
BLNK protein, human
Blnk protein, mouse
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b.
Y. Kitaura
,
I. Jang
,
+6 authors
Hua Gu
Immunity
2007
Corpus ID: 9462152
Review
2004
Review
2004
The SLP-76 family of adapter proteins.
Jennifer N. Wu
,
G. Koretzky
Seminars in Immunology
2004
Corpus ID: 41011198
Highly Cited
2001
Highly Cited
2001
BLNK mediates Syk-dependent Btk activation
Y. Baba
,
S. Hashimoto
,
+4 authors
S. Tsukada
Proceedings of the National Academy of Sciences…
2001
Corpus ID: 9614915
Btk is a critical molecule in B cell antigen receptor (BCR)-coupled signaling, and its activity is regulated by Lyn and Syk…
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Highly Cited
2001
Highly Cited
2001
Hematopoietic Progenitor Kinase 1 Associates Physically and Functionally with the Adaptor Proteins B Cell Linker Protein and SLP-76 in Lymphocytes*
K. Sauer
,
J. Liou
,
Suresh B. Singh
,
D. Yablonski
,
A. Weiss
,
R. Perlmutter
Journal of Biological Chemistry
2001
Corpus ID: 22707844
B cell linker protein (BLNK) is a SLP-76-related adaptor protein essential for signal transduction from the BCR. To identify…
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Highly Cited
2000
Highly Cited
2000
HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1.
Jen Liou
,
Friedemann Kiefer
,
+4 authors
Arthur Weiss
Immunity
2000
Corpus ID: 6667432
Highly Cited
2000
Highly Cited
2000
Cbl Suppresses B Cell Receptor–Mediated Phospholipase C (Plc)-γ2 Activation by Regulating B Cell Linker Protein–Plc-γ2 Binding
T. Yasuda
,
A. Maeda
,
+4 authors
T. Kurosaki
Journal of Experimental Medicine
2000
Corpus ID: 10477569
Accumulating evidence indicates that the Cbl protein plays a negative role in immune receptor signaling; however, the mode of Cbl…
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Highly Cited
1999
Highly Cited
1999
Requirement for B cell linker protein (BLNK) in B cell development.
R. Pappu
,
Alec M. Cheng
,
+6 authors
Andrew C. Chan
Science
1999
Corpus ID: 519517
Linker proteins function as molecular scaffolds to localize enzymes with substrates. In B cells, B cell linker protein (BLNK…
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Highly Cited
1999
Highly Cited
1999
Cutting edge: association of phospholipase C-gamma 2 Src homology 2 domains with BLNK is critical for B cell antigen receptor signaling.
M. Ishiai
,
Hitoshi Sugawara
,
M. Kurosaki
,
T. Kurosaki
Journal of Immunology
1999
Corpus ID: 30541920
To explore the mechanism(s) by which phospholipase C (PLC)-gamma 2 participates in B cell Ag receptor (BCR) signaling, we have…
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Highly Cited
1999
Highly Cited
1999
BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells.
M. Ishiai
,
M. Kurosaki
,
+7 authors
T. Kurosaki
Immunity
1999
Corpus ID: 41796303
Signaling through the B cell receptor (BCR) is essential for B cell function and development. Despite the key role of Syk in BCR…
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Highly Cited
1998
Highly Cited
1998
BLNK: a central linker protein in B cell activation.
C. Fu
,
Christoph W. Turck
,
Tomohiro Kurosaki
,
Andrew C. Chan
Immunity
1998
Corpus ID: 34390044
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