Role of BLNK in oxidative stress signaling in B cells.

@article{Han2001RoleOB,
  title={Role of BLNK in oxidative stress signaling in B cells.},
  author={Wang Bao Han and Tomoko Takano and Aurelie Desgardin and Junyi Ding and Shengfu Gao and Chieko Noda and Shigeru Yanagi and Hirohei Yamamura},
  journal={Antioxidants & redox signaling},
  year={2001},
  volume={3 6},
  pages={
          1065-73
        }
}
BLNK (B cell linker protein) represents a central linker protein that bridges the B cell receptor-associated kinases with a multitude of signaling pathways. In this study, we have investigated the role of BLNK in oxidative stress signaling in B cells. H2O2 treatment of B cells induced a rapid tyrosine phosphorylation of BLNK in a H2O2 dose-dependent manner, which was inhibited in Syk-deficient DT40 cells. Calcium mobilization in BLNK-deficient as well as Syk-deficient and phospholipase C (PLC… CONTINUE READING
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