• Publications
  • Influence
Autoreactive B Cell Responses to RNA-Related Antigens Due to TLR7 Gene Duplication
Antibodies against nuclear self-antigens are characteristic of systemic autoimmunity, although mechanisms promoting their generation and selection are unclear. Here, we report that B cells containingExpand
  • 743
  • 19
Redundant and Opposing Functions of Two Tyrosine Kinases, Btk and Lyn, in Mast Cell Activation1
Protein-tyrosine kinases play crucial roles in mast cell activation through the high-affinity IgE receptor (FcεRI). In this study, we have made the following observations on growth properties andExpand
  • 177
  • 11
Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells.
CD34 is a 115-kDa transmembrane glycoprotein of unknown function that is expressed on human hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. We have isolated aExpand
  • 249
  • 8
Xid-like phenotypes: a B cell signalosome takes shape.
The molecular events linking BCR stimulation to Ca2+ flux are coming into focus. Considering together the results of biochemical studies and mouse genetic analyses, strong support now exists for aExpand
  • 208
  • 6
Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain.
Bruton's tyrosine kinase (BTK) is a nonreceptor tyrosine kinase critical for B cell development and function. Mutations in BTK result in X-linked agammaglobulinemia (XLA) in humans and X-linkedExpand
  • 190
  • 6
NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation.
Aggregation of high-affinity receptors for immunoglobulin E (Fc epsilon RI) on the surface of mast cells results in degranulation, a response that is potentiated by binding of stem cell factor (SCF)Expand
  • 133
  • 6
  • PDF
Constitutive membrane association potentiates activation of Bruton tyrosine kinase
Mutations in the nonreceptor tyrosine kinase Btk result in the B cell immunodeficiencies X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (xid) in mice. Genetic andExpand
  • 78
  • 6
Independent and Opposing Roles For Btk and Lyn in B and Myeloid Signaling Pathways
Transphosphorylation by Src family kinases is required for the activation of Bruton's tyrosine kinase (Btk). Differences in the phenotypes of Btk−/− and lyn−/− mice suggest that these kinases mayExpand
  • 83
  • 6
  • PDF
Btk function in B cell development and response.
Mutations in Bruton's tyrosine kinase (Btk) result in the B cell immunodeficiencies XLA in humans and Xid in mice. Both the maintenance of peripheral B cell numbers and their response to B cellExpand
  • 168
  • 4
Reduced Dosage of Bruton’s Tyrosine Kinase Uncouples B Cell Hyperresponsiveness from Autoimmunity in lyn−/− Mice1
The development of autoimmunity is correlated with heightened sensitivity of B cells to B cell Ag receptor (BCR) cross-linking. BCR signals are down-regulated by Lyn, which phosphorylates inhibitoryExpand
  • 48
  • 4
  • PDF