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BIRC7 gene

Known as: melanoma inhibitor of apoptosis protein, livin inhibitor-of-apoptosis, RNF50 
This gene regulates apoptosis through dual transcriptional activation pathways.
National Institutes of Health

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ApoptosisBIRC7 protein, humanNegative Regulation of Apoptosis

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BIRC7 wt Allele

Papers overview

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Review
2011
Review
2011
Research progress on Livin protein: an inhibitor of apoptosis
Livin is a member of the inhibitors of apoptosis (IAP) family, which plays crucial roles in apoptosis, cell proliferation, and… 
Highly Cited
2007
Highly Cited
2007
Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia.
Livin, a member of the inhibitor of apoptosis proteins, has been considered to be a poor prognostic marker in malignancies… 
Highly Cited
2007
Highly Cited
2007
Livin and Bcl-2 expression in high-grade osteosarcoma
AimsThe evaluation of prognosis in patients with osteosarcoma is limited to clinical parameters. Although numerous molecular… 
Review
2007
Review
2007
Livin/melanoma inhibitor of apoptosis protein as a potential therapeutic target for the treatment of malignancy
Livin, also called melanoma inhibitor of apoptosis protein (IAP) or kidney IAP, is a member of the IAP family of caspase… 
Highly Cited
2006
Highly Cited
2006
Livin promotes Smac/DIABLO degradation by ubiquitin–proteasome pathway
Livin, a member of the inhibitor of apoptosis protein (IAP) family, encodes a protein containing a single baculoviral IAP repeat… 
Highly Cited
2005
Highly Cited
2005
Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.
ML-IAP (melanoma inhibitor of apoptosis) is a potent anti-apoptotic protein that is strongly up-regulated in melanoma and confers… 
Highly Cited
2005
Highly Cited
2005
Expression of Inhibitor-of-Apoptosis Protein (IAP) Livin by Neuroblastoma Cells: Correlation with Prognostic Factors and Outcome
Livin is a recently identified member of the Inhibitor-of-Apoptosis protein (IAP) family of antiapoptosis proteins, and… 
Highly Cited
2003
Highly Cited
2003
Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanoma.
Inhibitor of apoptosis protein (IAP) is a family of intracellular proteins that plays an essential role in the regulation of… 
Highly Cited
2001
Highly Cited
2001
Detection of anti-livin antibody in gastrointestinal cancer patients.
Livin, a recently described member of the inhibitor of apoptosis protein (IAP) family, contains a single baculovirus IAP repeat… 
Highly Cited
2000
Highly Cited
2000
KIAP, a novel member of the inhibitor of apoptosis protein family.
We have identified a novel human gene, kiap (kidney inhibitor of apoptosis protein) that encodes a single BIR domain and a RING… 
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