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BIN1 protein

Known as: BIN1, Amphiphysin II, Bridging Integrator 1 
Encoded as ten alternate splicing variant isoforms by human BIN1 Gene, ubiquitously expressed nucleocytoplasmic adaptor protein Bridging Integrator 1… 
National Institutes of Health

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Adaptor Proteins, Signal TransducingAdaptor Signaling Protein GeneBIN1 geneIntracellular Signaling Process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid
The mechanisms driving pathological beta‐amyloid (Aβ) generation in late‐onset Alzheimer's disease (AD) are unclear. Two late… 
Highly Cited
2016
Highly Cited
2016
Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts
Genome-wide association studies have identified BIN1 within the second most significant susceptibility locus in late-onset… 
Highly Cited
2012
Highly Cited
2012
Mechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment
Cisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin… 
Highly Cited
2011
Highly Cited
2011
Defects in amphiphysin 2 (BIN1) and triads in several forms of centronuclear myopathies
Myotubular myopathy and centronuclear myopathies (CNM) are congenital myopathies characterized by generalized muscle weakness and… 
Highly Cited
2011
Highly Cited
2011
c-MYC Suppresses BIN1 to Release Poly(ADP-Ribose) Polymerase 1: A Mechanism by Which Cancer Cells Acquire Cisplatin Resistance
c-MYC promotes cisplatin resistance by enabling the increased activity of a DNA repair enzyme. Losing Your Inhibitions The… 
Highly Cited
2009
Highly Cited
2009
2‐D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease
The mechanisms underlying white matter changes in psychiatric disease are not known. We aimed to characterise the differential… 
Highly Cited
1999
Highly Cited
1999
SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation
Several SH3-domain-containing proteins have been implicated in endocytosis by virtue of their interactions with dynamin; however… 
Highly Cited
1997
Highly Cited
1997
Amphiphysin II (SH3P9; BIN1), a Member of the Amphiphysin/Rvs Family, Is Concentrated in the Cortical Cytomatrix of Axon Initial Segments and Nodes of Ranvier in Brain and around T Tubules in…
Amphiphysin (amphiphysin I), a dominant autoantigen in paraneoplastic Stiff-man syndrome, is a neuronal protein highly… 
Highly Cited
1997
Highly Cited
1997
Identification and Characterization of a Nerve Terminal-enriched Amphiphysin Isoform*
Amphiphysin is a nerve terminal-enriched protein thought to function in synaptic vesicle endocytosis, in part through Src… 
Highly Cited
1997
Highly Cited
1997
Structural Analysis of the Human BIN1 Gene
BIN1 is a putative tumor suppressor that was identified through its interaction with the MYC oncoprotein. To begin to identify… 
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