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BIN1 protein

Known as: BIN1, Amphiphysin II, Bridging Integrator 1 
Encoded as ten alternate splicing variant isoforms by human BIN1 Gene, ubiquitously expressed nucleocytoplasmic adaptor protein Bridging Integrator 1… Expand
National Institutes of Health

Related topics

Related topics

7 relations
Adaptor Proteins, Signal TransducingAdaptor Signaling Protein GeneBIN1 geneIntracellular Signaling Process
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts
BackgroundGenome-wide association studies have identified BIN1 within the second most significant susceptibility locus in late… Expand
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Highly Cited
2015
Highly Cited
2015
Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease.
IMPORTANCE Recent large-scale genome-wide association studies have discovered several genetic variants associated with Alzheimer… Expand
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2014
2014
Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology.
Recent genome wide association studies have implicated bridging integrator 1 (BIN1) as a late-onset Alzheimer's disease (AD… Expand
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Highly Cited
2012
Highly Cited
2012
Mechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment
Cisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin… Expand
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Highly Cited
2012
Highly Cited
2012
BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes.
BACKGROUND Heart failure is a growing epidemic, and a typical aspect of heart failure pathophysiology is altered calcium… Expand
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Highly Cited
2010
Highly Cited
2010
BIN1 Localizes the L-Type Calcium Channel to Cardiac T-Tubules
The BAR domain protein superfamily is involved in membrane invagination and endocytosis, but its role in organizing membrane… Expand
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Highly Cited
2009
Highly Cited
2009
AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd in endocytic recycling
RME-1/EHD1 (receptor mediated endocytosis/Eps15 homology-domain containing 1) family proteins are key residents of the recycling… Expand
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Highly Cited
2007
Highly Cited
2007
Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy
Centronuclear myopathies are characterized by muscle weakness and abnormal centralization of nuclei in muscle fibers not… Expand
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Highly Cited
1999
Highly Cited
1999
SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation
Several SH3-domain-containing proteins have been implicated in endocytosis by virtue of their interactions with dynamin; however… Expand
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Highly Cited
1996
Highly Cited
1996
BIN1 is a novel MYC–interacting protein with features of a tumour suppressor
BIN1 is a novel protein that interacts with the functionally critical Myc box regions at the N terminus of the MYC oncoprotein… Expand
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