BIN1 gene

Known as: BRIDGING INTEGRATOR 1, AMPHIPHYSIN II, SH3P9 
This gene is involved in signal transduction and cell differentiation.
National Institutes of Health

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BIN1 proteinIntracellular Signaling ProcessLiver carcinomaSignal Transduction
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BIN1 wt Allele

Papers overview

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Review
2017
Review
2017
Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials
INTRODUCTION The Alzheimer's Disease Neuroimaging Initiative (ADNI) has continued development and standardization of… (More)
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Highly Cited
2013
Highly Cited
2013
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
We undertook a two-stage genome-wide association study of Alzheimer's disease involving over 16,000 individuals. In stage 1 (3… (More)
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Highly Cited
2013
Highly Cited
2013
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most important genetic… (More)
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Highly Cited
2011
Highly Cited
2011
Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy
Myotonic dystrophy is the most common muscular dystrophy in adults and the first recognized example of an RNA-mediated disease… (More)
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Highly Cited
2011
Highly Cited
2011
Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE
Late-onset Alzheimer's disease (LOAD) is the most common form of dementia in the elderly. The National Institute of Aging-Late… (More)
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Highly Cited
2011
Highly Cited
2011
Meta-Analysis for Genome-Wide Association Study Identifies Multiple Variants at the BIN1 Locus Associated with Late-Onset Alzheimer's Disease
Recent GWAS studies focused on uncovering novel genetic loci related to AD have revealed associations with variants near CLU, CR1… (More)
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Highly Cited
2011
Highly Cited
2011
Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals.
  • Archives of neurology
  • 2011
OBJECTIVES To identify novel loci for late-onset Alzheimer disease (LOAD) in Caribbean Hispanic individuals and to replicate the… (More)
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Highly Cited
2007
Highly Cited
2007
Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy
Centronuclear myopathies are characterized by muscle weakness and abnormal centralization of nuclei in muscle fibers not… (More)
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Highly Cited
1999
Highly Cited
1999
Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma.
Loss of tumor suppressors that restrain important oncoproteins such as c-Myc may contribute to malignant progression. Bin1 is an… (More)
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Highly Cited
1997
Highly Cited
1997
Amphiphysin II (SH3P9; BIN1), a Member of the Amphiphysin/Rvs Family, Is Concentrated in the Cortical Cytomatrix of Axon Initial Segments and Nodes of Ranvier in Brain and around T Tubules in…
Amphiphysin (amphiphysin I), a dominant autoantigen in paraneoplastic Stiff-man syndrome, is a neuronal protein highly… (More)
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