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BIN1 gene

Known as: BRIDGING INTEGRATOR 1, AMPHIPHYSIN II, SH3P9 
This gene is involved in signal transduction and cell differentiation.
National Institutes of Health

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Related topics

6 relations
BIN1 proteinIntracellular Signaling ProcessLiver carcinomaSignal Transduction
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BIN1 wt Allele

Papers overview

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Highly Cited
2014
Highly Cited
2014
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
Here, we leverage a unique collection of 708 prospectively collected autopsied brains to assess the methylation state of the… Expand
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Highly Cited
2014
Highly Cited
2014
Alzheimery's disease pathology is associated with early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
We used a collection of 708 prospectively collected autopsied brains to assess the methylation state of the brain's DNA in… Expand
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Highly Cited
2013
Highly Cited
2013
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most important genetic… Expand
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Highly Cited
2012
Highly Cited
2012
Tissue-specific alternative splicing remodels protein-protein interaction networks.
Alternative splicing plays a key role in the expansion of proteomic and regulatory complexity, yet the functions of the vast… Expand
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Highly Cited
2011
Highly Cited
2011
Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy
Myotonic dystrophy is the most common muscular dystrophy in adults and the first recognized example of an RNA-mediated disease… Expand
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Highly Cited
2011
Highly Cited
2011
Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE
Late-onset Alzheimer's disease (LOAD) is the most common form of dementia in the elderly. The National Institute of Aging-Late… Expand
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Highly Cited
2007
Highly Cited
2007
Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy
Centronuclear myopathies are characterized by muscle weakness and abnormal centralization of nuclei in muscle fibers not… Expand
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Highly Cited
1999
Highly Cited
1999
Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma.
Loss of tumor suppressors that restrain important oncoproteins such as c-Myc may contribute to malignant progression. Bin1 is an… Expand
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Highly Cited
1998
Highly Cited
1998
Crystal structure of the amphiphysin‐2 SH3 domain and its role in the prevention of dynamin ring formation
The amphiphysins are brain‐enriched proteins, implicated in clathrin‐mediated endocytosis, that interact with dynamin through… Expand
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Highly Cited
1997
Highly Cited
1997
Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis.
Amphiphysin (Amph) is a src homology 3 domain-containing protein that has been implicated in synaptic vesicle endocytosis as a… Expand
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