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Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to
TLDR
Down-regulation of Sox2, a human homolog of a chicken gastric transcription factor, may be important factors for the development of IM. Expand
BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers
TLDR
The data indicate that BCL6 interacts with nuclear-translocated HB-EGF-CTF and that the nuclear export and degradation of BCL7 induces cyclin D2 upregulation and real-time RT–PCR and siRNA targeting BCL 6 revealed that B CL6 suppresses cyclinD2 expression. Expand
Gastric-and-intestinal mixed-type intestinal metaplasia: aberrant expression of transcription factors and stem cell intestinalization
TLDR
It was suggested that IM might be caused by the gradual intestinalization of stem cells from the GI to the I type, and the molecular mechanisms include the ectopic expression of CDX1, CDX2, OCT-1, and members of the Erk pathway. Expand
Blockage of angiotensin II type 1 receptor regulates TNF-alpha-induced MAdCAM-1 expression via inhibition of NF-kappaB translocation to the nucleus and ameliorates colitis.
TLDR
Results suggest that AT1R regulates the expression of MAdCAM-1 under colonic inflammatory conditions through regulation of the translocation of NF-kappaB into the nucleus. Expand
Expression of Cdx2 and the phenotype of advanced gastric cancers: relationship with prognosis
TLDR
Combined evaluation of gastric and intestinal epithelial cell markers, including Cdx2, is clinically useful to predict outcome in patients with advanced neoplasm of the stomach. Expand
Sox2 expression in human stomach adenocarcinomas with gastric and gastric‐and‐intestinal‐mixed phenotypes
TLDR
It is reported that Sox2, an HMG‐box gastric transcription factor, is expressed in normal gastric mucosa and down‐regulated in intestinal metaplasia. Expand
High salt diets dose‐dependently promote gastric chemical carcinogenesis in Helicobacter pylori‐infected Mongolian gerbils associated with a shift in mucin production from glandular to surface mucous
TLDR
Reducing salt intake could be one of the most important chemopreventive methods for human gastric carcinogenesis in H. pylori‐infected Mongolian gerbils associated with alteration of the mucous microenvironment. Expand
Mechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment
TLDR
A new mechanism has recently been revealed, in which the oncoprotein c-Myc suppresses bridging integrator 1 (BIN1), thereby releasing poly(ADP-ribose)polymerase 1, which results in increased DNA repair activity and allows cancer cells to acquire cisplatin resistance. Expand
Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life.
TLDR
LNT combination from the beginning of the chemotherapy may be an important factor for the improvement of patient QOL and there were individual variations in the binding ratio of LNT to monocytes from 0.16% to 11.95%. Expand
Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa — with special emphasis on participation in intestinal metaplasia of the human
TLDR
Cdx1 and Cdx2 mRNAs are widely present in the human intestinal and colonic mucosae, but not in the gastric mucosa, suggesting that their expression may contribute to the intestinal phenotype. Expand
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