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BIIB021

Known as: BIIB-021 
 
National Institutes of Health

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Related topics

1 relation

Broader (1)

HSP90 inhibitor CNF2024

Papers overview

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2016
2016
Hsp90 inhibitor, BIIB021, induces apoptosis and autophagy by regulating mTOR-Ulk1 pathway in imatinib-sensitive and -resistant chronic myeloid leukemia cells.
  • W. He, X. Ye, +5 authors W. Qian
  • International journal of oncology
  • 2016
    • Corpus ID: 19753131
Development of drug resistance due to BCR-ABL point mutations and the persistence of leukemia initiating cells has become a major… Expand
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2016
2016
Synergistic cytotoxicity of BIIB021 with triptolide through suppression of PI3K/Akt/mTOR and NF-κB signal pathways in thyroid carcinoma cells.
The effec.t of BIIB021, a novel heat shock protein 90 (hsp90) inhibitor, on survival of thyroid carcinoma cells has not been… Expand
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Highly Cited
2013
Highly Cited
2013
Phase II study of the HSP90-inhibitor BIIB021 in gastrointestinal stromal tumors.
BACKGROUND HSP90 inhibition leads to proteosomal degradation of activated KIT and has in vitro activity against gastrointestinal… Expand
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2013
2013
A Phase 1, Dose-Escalation, Pharmacokinetic and Pharmacodynamic Study of BIIB021 Administered Orally in Patients with Advanced Solid Tumors
Purpose: BIIB021 is the first oral, synthetic, non-geldanamycin–based HSP90 inhibitor that showed activity in preclinical models… Expand
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Highly Cited
2010
Highly Cited
2010
BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy
Heat shock protein 90 (Hsp90) is a molecular chaperone that promotes the conformational maturation of numerous client proteins… Expand
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Highly Cited
2010
Highly Cited
2010
BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance
17‐AAG, the first‐generation clinical Hsp90 inhibitor, exhibits promising antitumor activity in clinical studies, but is limited… Expand
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Highly Cited
2009
Highly Cited
2009
BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90
Inhibition of heat shock protein 90 (Hsp90) results in the degradation of oncoproteins that drive malignant progression, inducing… Expand
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Highly Cited
2009
Highly Cited
2009
CUDC-305, a Novel Synthetic HSP90 Inhibitor with Unique Pharmacologic Properties for Cancer Therapy
Purpose: We designed and synthesized CUDC-305, an HSP90 inhibitor of the novel imidazopyridine class. Here, we report its unique… Expand
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2009
2009
Heat Shock Protein 90 Inhibitor BIIB021 (CNF2024) Depletes NF-κB and Sensitizes Hodgkin's Lymphoma Cells for Natural Killer Cell–Mediated Cytotoxicity
Purpose: In Hodgkin's lymphoma, constitutive activation of NF-κB promotes tumor cell survival and proliferation. The molecular… Expand
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2008
2008
BIIB021, an oral, synthetic non-ansamycin Hsp90 inhibitor: Phase I experience
2503 Background: BIIB021 is an oral fully synthetic Hsp90 inhibitor that is being developed for both solid and hematologic tumors… Expand
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