BCR-ABL Fusion Gene

Known as: BCR-ABL1 Fusion Gene, BCR/ABL1 Fusion Gene, BCR-ABL Oncogene 
A gene formed when pieces of chromosomes 9 and 22 break off and trade places. The ABL gene from chromosome 9 joins to the BCR gene on chromosome 22… (More)

Topic mentions per year

Topic mentions per year

1987-2017
010020019872017

Papers overview

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Highly Cited
2011
Highly Cited
2011
Imatinib therapy, which targets the oncogene product BCR-ABL, has transformed chronic myeloid leukemia (CML) from a life… (More)
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Highly Cited
2002
Highly Cited
2002
Through sequencing analysis of blood or bone marrow samples from patients with chronic myeloid leukemia, we identified BCR-ABL… (More)
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Highly Cited
2001
Highly Cited
2001
Clinical studies with the Abl tyrosine kinase inhibitor STI-571 in chronic myeloid leukemia demonstrate that many patients with… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND BCR-ABL, a constitutively activated tyrosine kinase, is the product of the Philadelphia chromosome. This enzyme is… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND BCR-ABL is a constitutively activated tyrosine kinase that causes chronic myeloid leukemia (CML). Since tyrosine… (More)
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Highly Cited
2000
Highly Cited
2000
Targeting the tyrosine kinase activity of Bcr-Abl with STI571 is an attractive therapeutic strategy in chronic myelogenous… (More)
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Highly Cited
1998
Highly Cited
1998
The number of genetic lesions necessary to generate leukemia in humans is unknown, but it is possible that certain specific… (More)
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Highly Cited
1997
Highly Cited
1997
The Philadelphia chromosome found in virtually all cases of chronic myeloid leukemia (CML) and in about one third of the cases of… (More)
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Highly Cited
1996
Highly Cited
1996
HE PHILADELPHIA (Ph) chromosome was the first T chromosomal abnormality associated with a specific malignant disease in humans… (More)
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Highly Cited
1994
Highly Cited
1994
Apoptosis is the major form of cell death associated with the action of chemotherapeutic agents on tumor cells, and therefore the… (More)
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