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BBR 3464

Known as: BBR-3464, BBR3464 
A cationic tri-nuclear platinum complex related to cisplatin. BBR 3464 binds to and forms DNA crosslinks and platinum-DNA adducts, preventing DNA… 
National Institutes of Health

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Related topics

2 relations

Broader (2)

Antineoplastic AgentsOrganoplatinum Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
New Developments and Approaches in the Platinum Arena
Following the introduction of cisplatin and the demonstration of its importance in the treatment of testicular and ovarian cancer… 
2007
2007
Low-Dose BBR3610 Toxicity in Colon Cancer Cells Is p53-Independent and Enhanced by Inhibition of Epidermal Growth Factor Receptor (ERBB1)-Phosphatidyl Inositol 3 Kinase Signaling
We have examined the mechanisms by which the multinuclear platinum chemotherapeutic BBR3610 kills human colon cancer cells… 
Highly Cited
2004
Highly Cited
2004
Long range 1,4 and 1,6-interstrand cross-links formed by a trinuclear platinum complex. Minor groove preassociation affects kinetics and mechanism of cross-link formation as well as adduct structure.
Reported here is a comparison of the kinetics of the stepwise formation of 1,4- and 1,6-GG interstrand cross-links by the… 
Highly Cited
2003
Highly Cited
2003
Reaction of polynuclear platinum antitumor compounds with reduced glutathione studied by multinuclear (1H, 1H-15N gradient heteronuclear single-quantum coherence, and 195Pt) NMR spectroscopy.
A possible explanation for the low bioavailability of platinum antitumor compounds is their high reactivity with the sulfur… 
Highly Cited
2002
Highly Cited
2002
Kinetic and equilibria studies of the aquation of the trinuclear platinum phase II anticancer agent [(trans-PtCl(NH(3))(2))(2)(mu-trans-Pt(NH(3))(2)(NH(2)(CH(2))(6)NH(2))(2))](4+) (BBR3464).
The hydrolysis profile of the bifunctional trinuclear phase II clinical agent [(trans-PtCl(NH(3))(2))(2)(mu-trans-Pt(NH(3))(2)(NH… 
Highly Cited
2002
Highly Cited
2002
Cooperative effects in long-range 1,4 DNA-DNA interstrand cross-links formed by polynuclear platinum complexes: an unexpected syn orientation of adenine bases outside the binding sites
Abstract. The novel phase II anticancer drug BBR3464 ([{trans-PtCl(NH3)2}2-µ-{trans-Pt(NH3)2(NH2(CH2)6NH2)2}](NO3)4) forms a 1,4… 
Highly Cited
2002
Highly Cited
2002
Retention of activity by the new generation platinum agent AMD0473 in four human tumour cell lines possessing acquired resistance to oxaliplatin.
Highly Cited
2001
Highly Cited
2001
Conformation, Recognition by High Mobility Group Domain Proteins, and Nucleotide Excision Repair of DNA Intrastrand Cross-links of Novel Antitumor Trinuclear Platinum Complex BBR3464*
The new antitumor trinuclear platinum compound [{trans-PtCl(NH3)2}2μ-trans-Pt(NH3)2{H2N(CH2)6NH2}2]4+(designated as BBR3464) is… 
2001
2001
Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum-spermidine species through hydrolytic cleavage of carbamates.
BBR3464 is a novel trinuclear platinum drug currently in Phase II clinical trials. Polyamine-bridged dinuclear platinum compounds… 
Highly Cited
1999
Highly Cited
1999
Comparison of cytotoxicity and cellular accumulation of polynuclear platinum complexes in L1210 murine leukemia cell lines.
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