Cooperative effects in long-range 1,4 DNA-DNA interstrand cross-links formed by polynuclear platinum complexes: an unexpected syn orientation of adenine bases outside the binding sites

@article{Qu2002CooperativeEI,
  title={Cooperative effects in long-range 1,4 DNA-DNA interstrand cross-links formed by polynuclear platinum complexes: an unexpected syn orientation of adenine bases outside the binding sites},
  author={Y. -G. Qu and Neel J. Scarsdale and My-Chau Tran and Nicholas P. Farrell},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2002},
  volume={8},
  pages={19-28}
}
The novel phase II anticancer drug BBR3464 ([{trans-PtCl(NH3)2}2-µ-{trans-Pt(NH3)2(NH2(CH2)6NH2)2}](NO3)4) forms a 1,4-interstrand cross-link adduct with the self-complementary DNA octamer 5′-d(ATG*TACAT)2-3′, with the two platinum atoms coordinated in the major groove at the N7 positions of guanines that are four base pairs apart on opposite DNA strands. The "central" tetraamine linker [trans-H2N(CH2)6NH2Pt(NH3)2NH2(CH2)6NH2] was located in or close to the minor groove. The adduct was… CONTINUE READING

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