Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

BACE2 gene

Known as: CEAP1, ASPARTIC-LIKE PROTEASE, 56-KD, BETA-SITE AMYLOID BETA A4 PRECURSOR PROTEIN-CLEAVING ENZYME 2 
This gene is involved in proteolytic processing.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Amyloids are often associated with pathologic processes such as in Alzheimer’s disease (AD), but can also underlie physiological… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Background: BACE1 inhibitors target the first step in Aβ formation and are tractable drugs for halting disease progression in… Expand
  • figure 1
  • figure 2
  • table 1
  • table 2
  • figure 3
Is this relevant?
Highly Cited
2006
Highly Cited
2006
  • X. Sun, G. He, W. Song
  • FASEB journal : official publication of the…
  • 2006
  • Corpus ID: 31786464
Amyloid β protein (Aβ), the major component of neuritic plaques in Alzheimer's disease (AD), is derived from APP by sequential… Expand
Is this relevant?
Highly Cited
2005
Highly Cited
2005
β-Secretase (BACE1) is the rate-limiting protease for the generation of the amyloid β-peptide (Aβ) in Alzheimer disease. Mice in… Expand
Is this relevant?
Highly Cited
2005
Highly Cited
2005
A transmembrane aspartyl protease termed β-site APP cleavage enzyme 1 (BACE1) that cleaves the amyloid-β precursor protein (APP… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Extracellular deposition of amyloid-β (Aβ) aggregates in the brain represents one of the histopathological hallmarks of Alzheimer… Expand
  • figure 2
  • figure 3
  • figure 4
  • figure 5
  • figure 7
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The full-length and ectodomain forms of β-site APP cleavage enzyme (BACE) have been cloned, expressed in Sf9 cells, and purified… Expand
  • table I
  • figure 1
  • figure 2
  • table II
  • table III
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Two β-secretases, BACE1 and BACE2, are involved in generation of Alzheimer's disease Aβ peptides. We report that secretion of A… Expand
  • figure 1
  • figure 3
Is this relevant?
Highly Cited
2001
Highly Cited
2001
BACE1 and BACE2 define a new subfamily of membrane-anchored aspartyl proteases. Both endoproteases share similar structural… Expand
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Beta-site amyloid precursor protein cleaving enzyme (BACE) is a novel transmembrane aspartic protease that possesses all the… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?