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Studies on the constituents of Juglans species. I. Structural determination of (4S)- and (4R)-4-hydroxy-alpha-tetralone derivatives from the fruit of Juglans mandshurica MAXIM. var. sieboldiana
Four enantiomerically pure new alpha-tetralones, (4S)- and (4R)-5-hydroxy-4-methoxy-alpha-tetralones and (4S)- and (4R)-5,8-dihydroxy-4-methoxy-alpha-tetralones were isolated, together with fiveExpand
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Five new glycosides from Hypericum erectum Thunb.
Five new glycosides, quercetin 3′-O-β-d-galactopyranoside (1), quercetin 3-O-(2″-acetyl)-β-d-glucopyranoside (2), 4,6-dihydroxy-2-methoxyphenyl 1-O-β-d-glucopyranoside (3),Expand
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Structural revision of oleoacteoside and oleoechinacoside
The structures of previously reported oleoacteoside and oleoechinacoside, both being caffeoyl phenylethanoid glycosides (acteoside, echinacoside) esterified with an oleoside 11-methyl ester, wereExpand
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Chemical constituents of Hypericum erectum Thunb.
Twenty-two known constituents, including four xanthones, nine flavonoids and nine phenolic glycosides, were isolated from Hypericum erectum Thunb. Their structures were elucidated on the basis ofExpand
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Expeditious and Stereoselective Synthesis of Chiral trans-β-Hydroxy-δ-lactone Systems
Expeditious and stereoselective synthesis of chiral trans-β-hydroxy-δ-lactone systems starting from γ,δ-epoxy acrylates is described which involves the regioselective ring opening of an epoxide andExpand
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Structure-Based Design of Selective beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2.
BACE1 inhibitors hold potential as agents in disease-modifying treatment for Alzheimer’s disease. BACE2 cleaves the melanocyte protein PMEL in pigment cells of the skin and eye, generating melaninExpand
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