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B-Cell Lymphoma/Leukemia 11B

Known as: BCL-11B, hRit1, COUP-TF-Interacting Protein 2 
B-cell lymphoma/leukemia 11B (894 aa, ~96 kDa) is encoded by the human BCL11B gene. This protein may play a role in the modulation of p53-mediated… 
National Institutes of Health

Related topics

Related topics

5 relations
BCL11B geneCYS2-HIS2 Zinc FingersGenes, RegulatorHomo sapiens

Papers overview

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Highly Cited
2018
Highly Cited
2018
Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells
Highly Cited
2014
Highly Cited
2014
Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential
Two interleukin-7 receptor mutants identified in human early T cell precursor leukemia are sufficient to induce disease in mice… 
Highly Cited
2012
Highly Cited
2012
Global Methylation Profiling for Risk Prediction of Prostate Cancer
Purpose: The aim of this study was to investigate the promoter hypermethylation as diagnostic markers to detect malignant… 
Highly Cited
2012
Highly Cited
2012
Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia.
Adult T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor associated with poor outcome. In this study… 
Highly Cited
2010
Highly Cited
2010
Genome-wide DNA methylation profiling of chronic lymphocytic leukemia allows identification of epigenetically repressed molecular pathways with clinical impact
We performed a genome-wide analysis of aberrant DNA methylation in chronic lymphocytic leukemia (CLL) using methylated CpG island… 
Highly Cited
2006
Highly Cited
2006
BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes.
BCL11A and BCL11B are transcriptional regulators important for lymphopoiesis and previously associated with hematopoietic… 
Highly Cited
2006
Highly Cited
2006
The BCL11AXL transcription factor: its distribution in normal and malignant tissues and use as a marker for plasmacytoid dendritic cells
The BCL11A XL transcription factor: its distribution in normal and malignant tissues and use as a marker for plasmacytoid… 
Highly Cited
2004
Highly Cited
2004
Various types of rearrangements target TLX3 locus in T‐cell acute lymphoblastic leukemia
Most chromosomal translocations observed in T‐cell acute lymphoblastic leukemia (T‐ALL) often produce transcriptional activation… 
Highly Cited
2003
Highly Cited
2003
Bcl11b is required for differentiation and survival of αβ T lymphocytes
The gene Bcl11b, which encodes zinc finger proteins, and its paralog, Bcl11a, are associated with immune-system malignancies. We… 
Highly Cited
2003
Highly Cited
2003
The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2).
A cryptic chromosome rearrangement, t(5;14)(q35.1;q32.2), recently identified in pediatric acute lymphoblastic leukemia (ALL… 
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