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COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein.
It is demonstrated that CTIP1 is a sequence-specific DNA binding protein and a bona fide transcriptional repressor that is capable of functioning independently of COUP-TF family members. Expand
Fzf1p of Saccharomyces cerevisiae is a positive regulator of SSU1 transcription and its first zinc finger region is required for DNA binding
The FZF1 gene of Saccharomyces cerevisiae encodes a five‐zinc‐finger transcription factor involved in sulphite tolerance, and the Fzf1 protein was shown to bind to it directly in vitro. Expand
Involvement of the Histone Deacetylase SIRT1 in Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF)-interacting Protein 2-mediated Transcriptional Repression*
Findings implicate SIRT1 as a histone H3/H4 deacetylase in mammalian cells and in transcriptional repression mediated by CTIP2, and co-purified from Jurkat cell nuclear extracts in the context of a large (1–2 mDa) complex. Expand
Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear
Two novel and related C2H2 zinc finger proteins that are highly expressed in the brain, CTIP1 and CTIP2 (COUPTF-interacting proteins1 and 2, respectively), were isolated and shown to interact withExpand
Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells.
It is established that Bcl11b sustains mature ILC2 genetic and functional programs and lineage fidelity and is more than just a T-cell-only transcription factor. Expand
CTIP1 and CTIP2 are differentially expressed during mouse embryogenesis.
The results support the selective contributions of both CTIP1 and CTIP2 in the development and function of both the central nervous and immune systems and the importance of future investigations to define the function(s) of both proteins. Expand
Interaction of GRASP, a Protein encoded by a Novel Retinoic Acid-induced Gene, with Members of the Cytohesin Family of Guanine Nucleotide Exchange Factors*
A novel, retinoic acid-induced gene, GRP1-associated scaffoldprotein (GRASP), was isolated from P19 embryonal carcinoma cells using a subtractive screening strategy and interacted strongly with the General Receptor for Phosphoinositides 1 (GRP1), a brefeldin A-insensitive guanine nucleotide exchange factor for the ADP-ribosylation factor family of proteins. Expand
p300 Functions as a Coactivator for the Peroxisome Proliferator-activated Receptor α*
The integrator protein, p300, was demonstrated to interact with mouse peroxisome proliferator-activated receptor α in a ligand-enhanced manner and can be considered a bona fide coactivator for this nuclear receptor. Expand
Identification of Nuclear Receptor Corepressor as a Peroxisome Proliferator-activated Receptor α Interacting Protein*
Nuclear receptor corepressor appears to influence PPARα signaling pathways and, therefore, may modulate tissue responsiveness to peroxisome proliferators. Expand
BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter
The association of the endogenous BCL11B with the nucleosome remodeling and histone deacetylase (NuRD) complex, one of the major transcriptional corepressor complexes in mammalian cells, is demonstrated and the hypothesis that the NuRD complex mediates transcriptional repression function of BCL 11B is supported. Expand