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Azaguanine

Known as: 5-Amino-7-hydroxy-1H-v-triazolo(d)pyrimidine, 8 Azaguanine, Azaguanine [Chemical/Ingredient] 
A purine analogue with potential antineoplastic activity. 8-Azaguanine interferes with the modification of transfer ribonucleic acid (tRNA) by… 
National Institutes of Health

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9 relations

Broader (1)

Antimetabolites, Antineoplastic
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Papers overview

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1974
1974
Nature of mutations conferring resistance to 8-azaguanine in mouse cell lines.
Two stable mouse cell mutants A9 and RAG, which are resistant to 8-azaguanine and deficient in hypoxanthine-guanine… 
1973
1973
Biochemical characteristics of 8-azaguanine resistant human lymphoblast mutants selected in vitro.
Much of recent progress in our understanding of the regulation of purine metabolism in man has resulted from in vitro studies on… 
Review
1959
Review
1959
A mechanism of resistance to 8-azaguanine. I. Microbiological studies on the metabolism of purines and 8 azapurines.
The problem of drug resistance is recognized by clinicians and experimentalists as one of the major difficulties in the… 
Highly Cited
1957
Highly Cited
1957
Effects of combinations of azaserine and of 6-diazo-5-oxo-L-norleucine with purine analogs and other antimetabolites on the growth of two mouse mammary carcinomas.
1. Combined treatment of mice bearing the RC mammary carcinoma with azaserine or DON, on the one hand, and 6-mercaptopurine, 6… 
Highly Cited
1957
Highly Cited
1957
Effect of Benzimidazole on Detached Wheat Leaves
DETACHED wheat leaves when floated on water retain their green colour for a few days only and are usually chlorotic within a week… 
1954
1954
The effect of 4-amino-5-imidazolecarboxamide on the toxicity of 8-azaguanine.
The guanine analog, 8-azaguanine, has been shown to possess carcinostatic properties against transplantable tumors in… 
Highly Cited
1952
Highly Cited
1952
Enzymatic deamination of 8-azaguanine in normal and neoplastic tissues.
Summary 1.The enzymatic deamination of 8-azaguanine by homogenates of normal and neoplastic tissues of mice and rabbits has been… 
Highly Cited
1951
Highly Cited
1951
Observations on inhibition of nucleic acid synthesis resulting from administration of nitrogen mustard, urethan,. colchicine, 2,6-diaminopurine, 8-azaguanine, potassium arsenite, and cortisone.
Using the technic of measuring the incorporation of formate carbon into nucleic acid purines of control and treated mice, data… 
Highly Cited
1950
Highly Cited
1950
Investigation of the Nucleic Acids of Viscera and Tumor Tissue from Animals Injected with Radioactive 8-Azaguanine
Summary 1.Radioactive carbon from carbon-labeled 8-azaguanine, at 6 and 24 hours after injection, is found in higher… 
1950
1950
The effect of 5-amino-7-hydroxy-1H-v-triazolo (d) pyrimidine (guanazolo) on variety of neoplasms in experimental animals.
The action of the guanine analog, 5-amino-7-hydroxy-1 H - v -triazolo ( d ) pyrimidine, on a variety of experimental tumors has…