The effect of 4-amino-5-imidazolecarboxamide on the toxicity of 8-azaguanine.


The guanine analog, 8-azaguanine, has been shown to possess carcinostatic properties against transplantable tumors in experimental animals (7, 8). I t was believed that the compound inhibited the proliferation of tumor cells by acting as an antimetabolite in the biosynthesis of nucleic acid purines of the neoplastic tissue. To elucidate the mechanism of… (More)


1 Figure or Table