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IL-17 is a proinflammatory cytokine that activates T cells and other immune cells to produce a variety of cytokines, chemokines… Expand Summary: Naturally arising CD25+CD4+ regulatory T (Treg) cells, most of which are produced by the normal thymus as a… Expand Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a common p40 subunit shared with IL-12. IL… Expand Interleukin (IL)-2 plays a crucial role in the maintenance of natural immunologic self-tolerance. Neutralization of circulating… Expand Interleukin (IL) 23 is a heterodimeric cytokine composed of a p19 subunit and the p40 subunit of IL-12. IL-23 affects memory T… Expand Activation of naive CD4+ T-helper cells results in the development of at least two distinct effector populations, Th1 and Th2… Expand B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic cells in… Expand One of the predictions of the clonal selection theory was the ability of mature peripheral lymphocytes to discriminate between… Expand Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2… Expand INSULIN-DEPENDENT diabetes mellitus (IDDM) in non-obese diabetic (NOD) mice results from the T-lymphocyte-mediated destruction of… Expand