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Ataxin-7

Known as: Ataxin-7 [Chemical/Ingredient], Atxn 7 Protein, Spinocerebellar Ataxia 7 Protein 
A component of the STAGA transcription coactivator-HAT complex that functions in Cone Rod Homeobox Protein (CRX)-dependent gene activation. It also… Expand
National Institutes of Health

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ATXN7 protein, human
Ataxia, SpinocerebellarIn BloodProcess of secretionagonists
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Papers overview

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Highly Cited
2011
Highly Cited
2011
CTCF Regulates Ataxin-7 Expression through Promotion of a Convergently Transcribed, Antisense Noncoding RNA
Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder caused by CAG/polyglutamine repeat expansions in the ataxin… Expand
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Highly Cited
2008
Highly Cited
2008
Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export
Targeting of a gene to the nuclear pore complexes (NPCs), known as gene gating, can affect its transcriptional state. However… Expand
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Highly Cited
2006
Highly Cited
2006
Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport
Non-neuronal cells may be pivotal in neurodegenerative disease, but the mechanistic basis of this effect remains ill-defined. In… Expand
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Highly Cited
2005
Highly Cited
2005
Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration.
Spinocerebellar ataxia type 7 (SCA7) is characterized by cone-rod dystrophy retinal degeneration and is caused by a polyglutamine… Expand
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Highly Cited
2004
Highly Cited
2004
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes.
Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder caused by a CAG repeat expansion in the SCA7 gene leading to… Expand
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Review
2003
Review
2003
Pathogenesis of polyglutamine disorders: aggregation revisited.
Expansion of CAG trinucleotide repeats coding for polyglutamine in unrelated proteins causes at least nine late-onset progressive… Expand
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Highly Cited
2003
Highly Cited
2003
Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics.
The spinocerebellar ataxias (SCAs) are a class of hereditary neurodegenerative diseases, which are caused by the pathological… Expand
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Highly Cited
2003
Highly Cited
2003
SCA7 Knockin Mice Model Human SCA7 and Reveal Gradual Accumulation of Mutant Ataxin-7 in Neurons and Abnormalities in Short-Term Plasticity
We targeted 266 CAG repeats (a number that causes infantile-onset disease) into the mouse Sca7 locus to generate an authentic… Expand
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Highly Cited
2002
Highly Cited
2002
Polyglutamine-Expanded Ataxin-7 Promotes Non-Cell-Autonomous Purkinje Cell Degeneration and Displays Proteolytic Cleavage in Ataxic Transgenic Mice
Spinocerebellar ataxia (SCA) type 7 is an inherited neurodegenerative disorder caused by expansion of a polyglutamine tract… Expand
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Highly Cited
2001
Highly Cited
2001
Polyglutamine-Expanded Ataxin-7 Antagonizes CRX Function and Induces Cone-Rod Dystrophy in a Mouse Model of SCA7
Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant disorder caused by a CAG repeat expansion. To determine the… Expand
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