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Ataxin-7
Known as:
Ataxin-7 [Chemical/Ingredient]
, Atxn 7 Protein
, Spinocerebellar Ataxia 7 Protein
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A component of the STAGA transcription coactivator-HAT complex that functions in Cone Rod Homeobox Protein (CRX)-dependent gene activation. It also…
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National Institutes of Health
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Related topics
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10 relations
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ATXN7 protein, human
Ataxia, Spinocerebellar
In Blood
Process of secretion
agonists
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7
U. Rüb
,
L. Schöls
,
+6 authors
T. Deller
Progress in neurobiology
2013
Corpus ID: 24793695
Highly Cited
2008
Highly Cited
2008
Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export
A. Köhler
,
Maren Schneider
,
Ghislain G. Cabal
,
U. Nehrbass
,
E. Hurt
Nature Cell Biology
2008
Corpus ID: 33915569
Targeting of a gene to the nuclear pore complexes (NPCs), known as gene gating, can affect its transcriptional state. However…
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Highly Cited
2006
Highly Cited
2006
Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport
S. Custer
,
G. Garden
,
+8 authors
A. Spada
Nature Neuroscience
2006
Corpus ID: 8702315
Non-neuronal cells may be pivotal in neurodegenerative disease, but the mechanistic basis of this effect remains ill-defined. In…
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Highly Cited
2005
Highly Cited
2005
Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration.
V. Palhan
,
Shiming Chen
,
+6 authors
R. Roeder
Proceedings of the National Academy of Sciences…
2005
Corpus ID: 14428921
Spinocerebellar ataxia type 7 (SCA7) is characterized by cone-rod dystrophy retinal degeneration and is caused by a polyglutamine…
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Highly Cited
2004
Highly Cited
2004
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes.
D. Helmlinger
,
Sara Hardy
,
+10 authors
D. Devys
Human Molecular Genetics
2004
Corpus ID: 9949223
Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder caused by a CAG repeat expansion in the SCA7 gene leading to…
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Review
2003
Review
2003
Pathogenesis of polyglutamine disorders: aggregation revisited.
A. Michalik
,
C. van Broeckhoven
Human Molecular Genetics
2003
Corpus ID: 18298442
Expansion of CAG trinucleotide repeats coding for polyglutamine in unrelated proteins causes at least nine late-onset progressive…
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Highly Cited
2003
Highly Cited
2003
Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics.
Hartmut Scheel
,
S. Tomiuk
,
K. Hofmann
Human Molecular Genetics
2003
Corpus ID: 13485717
The spinocerebellar ataxias (SCAs) are a class of hereditary neurodegenerative diseases, which are caused by the pathological…
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Highly Cited
2002
Highly Cited
2002
Polyglutamine-Expanded Ataxin-7 Promotes Non-Cell-Autonomous Purkinje Cell Degeneration and Displays Proteolytic Cleavage in Ataxic Transgenic Mice
G. Garden
,
R. Libby
,
+13 authors
A. Spada
Journal of Neuroscience
2002
Corpus ID: 11633370
Spinocerebellar ataxia (SCA) type 7 is an inherited neurodegenerative disorder caused by expansion of a polyglutamine tract…
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Highly Cited
2001
Highly Cited
2001
Polyglutamine-Expanded Ataxin-7 Antagonizes CRX Function and Induces Cone-Rod Dystrophy in a Mouse Model of SCA7
A. Spada
,
Ying-Hui Fu
,
+14 authors
Shiming Chen
Neuron
2001
Corpus ID: 51784415
Highly Cited
1999
Highly Cited
1999
Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7.
M. D. Kaytor
,
L. Duvick
,
P. Skinner
,
M. Koob
,
L. Ranum
,
H. Orr
Human Molecular Genetics
1999
Corpus ID: 24386759
Spinocerebellar ataxia type 7 (SCA7) belongs to a group of neurological disorders caused by a CAG repeat expansion in the coding…
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