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Ataxin-1

Known as: Ataxin 1, Spinocerebellar Ataxia Type 1 Protein, SCA1 Protein 
A chromatin-binding factor that represses Notch signaling and associates with RNA. Expansion of the polyglutamine tract by expanded CAG repeats in… 
National Institutes of Health

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10 relations
ATXN1 geneAtaxia, SpinocerebellarIn BloodProcess of secretion

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Characterization of the AXH domain of Ataxin‐1 using enhanced sampling and functional mode analysis
Ataxin‐1 is the protein responsible for the Spinocerebellar ataxia type 1, an incurable neurodegenerative disease caused by… 
2016
2016
Conformational fluctuations of the AXH monomer of Ataxin‐1
In this paper, we report the results of molecular dynamics simulations of AXH monomer of Ataxin‐1. The AXH domain plays a crucial… 
2009
2009
Glial Cell Lineage Expression of Mutant Ataxin-1 and Huntingtin Induces Developmental and Late-Onset Neuronal Pathologies in Drosophila Models
Background In several neurodegenerative disorders, toxic effects of glial cells on neurons are implicated. However the generality… 
2009
2009
An interstitial deletion of 7.1Mb in chromosome band 6p22.3 associated with developmental delay and dysmorphic features including heart defects, short neck, and eye abnormalities.
2004
2004
General transcriptional repression by polyglutamine disease proteins is not directly linked to the presence of inclusion bodies.
2004
2004
Stress responses of PML nuclear domains are ablated by ataxin‐1 and other nucleoprotein inclusions
The polyglutamine diseases are characterized by expansion of triplet CAG repeats that encode polyglutamine tracts in otherwise… 
2004
2004
Prominent expression of spinocerebellar ataxia type-1 (SCA1) gene encoding ataxin-1 in LH-producing cells, LbetaT2.
The LH-producing cell line, LbetaT2, and non LH-producing cell line, alphaT3-1 cells, established from a pituitary tumor, were… 
2002
2002
Amino acids in a region of ataxin-1 outside of the polyglutamine tract influence the course of disease in SCA1 transgenic mice
Spinocerebellar ataxia type 1 (SCA1) belongs to a family of polyglutamine induced neurodegenerative disorders. Transgenic mice… 
1999
1999
Ataxin 1 and ataxin 3 in neuronal intranuclear inclusion disease.
Neuronal intranuclear inclusion disease (NIID) is a multisystem neurodegenerative disorder characterized by large intranuclear… 
1999
1999
Disassembly of nuclear inclusions in the dividing cell--a novel insight into neurodegeneration.
Spinocerebellar ataxias and Huntington's disease are examples of neurodegenerative diseases caused by a trinucleotide repeat… 
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