Anthramycin

Known as: Anthramycin [Chemical/Ingredient], 2-Propenamide, 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-, (11R-(2(E),11alpha,11abeta))-, Antramycin 
A pyrrolo(1,4)benzodiazepine antineoplastic antibiotic isolated from the bacterium Streptomyces refuineus var. thermotolerans. Anthramycin binds… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1965-2017
0246819652017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
The reassembly and heterologous expression of complete gene clusters in shuttle vectors has enabled investigations of several… (More)
  • figure 1
  • figure 2
  • table 1
Is this relevant?
2006
2006
The anticancer drug anthramycin inhibits replication and transcription processes by covalently binding to DNA. Here, we use… (More)
Is this relevant?
1997
1997
The interactions of several pyrrolo[2, 1-c][1,4]benzodiazepine (PBD) antitumor antibiotics with linearized plasmid pGEM-2-N-ras… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Ecteinascidin 743 is one of several related marine alkaloids isolated from the Caribbean tunicate Ecteinascidia turbinata. It is… (More)
Is this relevant?
1994
1994
The cellular pharmacology of a series of C8-linked pyrrolobenzodiazepine dimers with polymethylene linkers of n = 3-6 (compounds… (More)
  • table I
  • table II
Is this relevant?
1988
1988
The binding of the anti-tumor antibiotic anthramycin to a defined linear DNA fragment was investigated using both exonuclease III… (More)
Is this relevant?
1986
1986
We present molecular mechanics simulation of the covalent interactions of the potent antitumor antibiotic belonging to the… (More)
Is this relevant?
1979
1979
Anthramycin, an antitumour antibiotic produced by Streptomyces refuineus1, belongs to the pyrrolo(1,4)benzodiazepine antibiotic… (More)
Is this relevant?
Highly Cited
1978
Highly Cited
1978
A subline of P388 leukemia resistant to adriamycin (P388/ADR) was developed by exposure to the drug in vivo. Resistance to… (More)
Is this relevant?
1971
1971
The activity of anthramycin and structurally related analogs as chemosterilants of the housefly, Musca domestica L., correlates… (More)
Is this relevant?