Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Anthramycin

Known as: Anthramycin [Chemical/Ingredient], 2-Propenamide, 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-, (11R-(2(E),11alpha,11abeta))-, Antramycin 
A pyrrolo(1,4)benzodiazepine antineoplastic antibiotic isolated from the bacterium Streptomyces refuineus var. thermotolerans. Anthramycin binds… Expand
National Institutes of Health

Related topics

Related topics

14 relations

Narrower (5)

1,11a-didehydroanhydroanthramycinabbeymycinanthramycin 11-methyl ethermazethramycin
Expand

Broader (2)

Antibiotics, AntineoplasticBenzodiazepinones
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
Expand

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody–Drug Conjugates (ADCs)
Abstract The pyrrolo[2,1‐c][1,4]benzodiazepines (PBDs) are a family of sequence‐selective DNA minor‐groove binding agents that… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Review
2011
Review
2011
Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).
Pyrrolobenzodiazepines (PBD) are an important class of sequence-selective DNA-interactive agents that bind covalently to guanine… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 4
Highly Cited
2009
Highly Cited
2009
Biosynthesis of Sibiromycin, a Potent Antitumor Antibiotic
ABSTRACT Pyrrolobenzodiazepines, a class of natural products produced by actinomycetes, are sequence selective DNA alkylating… Expand
Review
2004
Review
2004
DNA minor groove binders as potential antitumor and antimicrobial agents
DNA minor groove binders constitute an important class of derivatives in anticancer therapy. Some of these compounds form… Expand
Highly Cited
1996
Highly Cited
1996
DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata.
Ecteinascidin 743 is one of several related marine alkaloids isolated from the Caribbean tunicate Ecteinascidia turbinata. It is… Expand
Highly Cited
1994
Highly Cited
1994
Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity.
A 2.3-A X-ray crystal structure analysis has been carried out on the antitumor drug anthramycin, covalently bound to a ten base… Expand
Review
1986
Review
1986
Nonintercalating DNA-binding ligands: specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material.
II. DNA BINDING ANTIBIOTICS 1. Pyrrole-Amidine Antibiotics and Synthetic Analogues (a) Structure and physical properties (b… Expand
Highly Cited
1979
Highly Cited
1979
Proposed structure of the anthramycin–DNA adduct
Anthramycin, an antitumour antibiotic produced by Streptomyces refuineus1, belongs to the pyrrolo(1,4)benzodiazepine antibiotic… Expand
Review
1977
Review
1977
Pyrrolo(1,4)benzodiazepine antitumor antibiotics. Comparative aspects of anthramycin, tomaymycin and sibiromycin.
  • L. Hurley
  • The Journal of antibiotics
  • 1977
    • Corpus ID: 40236845
Anthramycin, sibiromycin and tomaymycin are structurally related antibiotics produced by various actinomycetes. Anthramycin was… Expand
Highly Cited
1965
Highly Cited
1965
Isolation and characterization of anthramycin, a new antitumor antibiotic.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE