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Anthramycin

Known as: Anthramycin [Chemical/Ingredient], 2-Propenamide, 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-, (11R-(2(E),11alpha,11abeta))-, Antramycin 
A pyrrolo(1,4)benzodiazepine antineoplastic antibiotic isolated from the bacterium Streptomyces refuineus var. thermotolerans. Anthramycin binds… Expand
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Pyrrolobenzodiazepines (PBD) are an important class of sequence-selective DNA-interactive agents that bind covalently to guanine… Expand
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2011
2011
We report the first characterization and classification of Orf13 (S. refuineus) as a heme-dependent peroxidase catalyzing the… Expand
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Highly Cited
2009
Highly Cited
2009
Pyrrolobenzodiazepines, a class of natural products produced by actinomycetes, are sequence selective DNA alkylating compounds… Expand
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2008
2008
The reassembly and heterologous expression of complete gene clusters in shuttle vectors has enabled investigations of several… Expand
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Highly Cited
1996
Highly Cited
1996
Ecteinascidin 743 is one of several related marine alkaloids isolated from the Caribbean tunicate Ecteinascidia turbinata. It is… Expand
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Highly Cited
1996
Highly Cited
1996
The mechanism by which mammalian nucleotide excision repair (NER) detects a wide range of base lesions is poorly understood. Here… Expand
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1994
1994
A 2.3-A X-ray crystal structure analysis has been carried out on the antitumor drug anthramycin, covalently bound to a ten base… Expand
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Review
1986
Review
1986
II. DNA BINDING ANTIBIOTICS 1. Pyrrole-Amidine Antibiotics and Synthetic Analogues (a) Structure and physical properties (b… Expand
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1985
1985
The binding constants for interaction of the anticancer agents mitoxantrone and ametantrone and several congeners with calf… Expand
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1965