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Anthramycin
Known as:
Anthramycin [Chemical/Ingredient]
, 2-Propenamide, 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-, (11R-(2(E),11alpha,11abeta))-
, Antramycin
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A pyrrolo(1,4)benzodiazepine antineoplastic antibiotic isolated from the bacterium Streptomyces refuineus var. thermotolerans. Anthramycin binds…
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National Institutes of Health
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Related topics
Related topics
14 relations
Narrower (5)
1,11a-didehydroanhydroanthramycin
abbeymycin
anthramycin 11-methyl ether
mazethramycin
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Broader (2)
Antibiotics, Antineoplastic
Benzodiazepinones
In Blood
agonists
analogs & derivatives
antagonists & inhibitors
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody–Drug Conjugates (ADCs)
Julia Mantaj
,
P. Jackson
,
K. M. Rahman
,
D. Thurston
Angewandte Chemie
2016
Corpus ID: 6153280
Abstract The pyrrolo[2,1‐c][1,4]benzodiazepines (PBDs) are a family of sequence‐selective DNA minor‐groove binding agents that…
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Highly Cited
2009
Highly Cited
2009
Biosynthesis of Sibiromycin, a Potent Antitumor Antibiotic
Wei Li
,
A. Khullar
,
S. Chou
,
Ashley Sacramo
,
B. Gerratana
Applied and Environmental Microbiology
2009
Corpus ID: 8030493
ABSTRACT Pyrrolobenzodiazepines, a class of natural products produced by actinomycetes, are sequence selective DNA alkylating…
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Highly Cited
2007
Highly Cited
2007
Benzodiazepine biosynthesis in Streptomyces refuineus.
Yunfeng Hu
,
V. Phelan
,
Ioanna Ntai
,
C. Farnet
,
E. Zazopoulos
,
B. Bachmann
Chemistry and Biology
2007
Corpus ID: 23648322
Review
1999
Review
1999
Synthetic DNA minor groove-binding drugs.
B. S. Reddy
,
S. Sondhi
,
J. Lown,
Pharmacology and Therapeutics
1999
Corpus ID: 22157625
Highly Cited
1996
Highly Cited
1996
DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata.
Y. Pommier
,
G. Kohlhagen
,
C. Bailly
,
M. Waring
,
A. Mazumder
,
K. Kohn
Biochemistry
1996
Corpus ID: 34870018
Ecteinascidin 743 is one of several related marine alkaloids isolated from the Caribbean tunicate Ecteinascidia turbinata. It is…
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Review
1994
Review
1994
Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).
Dyeison Antonow
,
D. Thurston
Chemical Reviews
1994
Corpus ID: 30372903
Pyrrolobenzodiazepines (PBD) are an important class of sequence-selective DNA-interactive agents that bind covalently to guanine…
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Highly Cited
1994
Highly Cited
1994
Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity.
M. Kopka
,
D. Goodsell
,
I. Baikalov
,
K. Grześkowiak
,
D. Cascio
,
R. Dickerson
Biochemistry
1994
Corpus ID: 44840853
A 2.3-A X-ray crystal structure analysis has been carried out on the antitumor drug anthramycin, covalently bound to a ten base…
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Review
1986
Review
1986
Nonintercalating DNA-binding ligands: specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material.
C. Zimmer
,
U. Wähnert
Progress in Biophysics and Molecular Biology
1986
Corpus ID: 42558265
Highly Cited
1979
Highly Cited
1979
Proposed structure of the anthramycin–DNA adduct
L. Hurley
,
R. Petrusek
Nature
1979
Corpus ID: 4308335
Anthramycin, an antitumour antibiotic produced by Streptomyces refuineus1, belongs to the pyrrolo(1,4)benzodiazepine antibiotic…
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Review
1977
Review
1977
Pyrrolo(1,4)benzodiazepine antitumor antibiotics. Comparative aspects of anthramycin, tomaymycin and sibiromycin.
L. Hurley
Journal of antibiotics (Tokyo. )
1977
Corpus ID: 40236845
Anthramycin, sibiromycin and tomaymycin are structurally related antibiotics produced by various actinomycetes. Anthramycin was…
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