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Anthramycin

Known as: Anthramycin [Chemical/Ingredient], 2-Propenamide, 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-, (11R-(2(E),11alpha,11abeta))-, Antramycin 
A pyrrolo(1,4)benzodiazepine antineoplastic antibiotic isolated from the bacterium Streptomyces refuineus var. thermotolerans. Anthramycin binds… Expand
National Institutes of Health

Related topics

Related topics

14 relations

Narrower (5)

1,11a-didehydroanhydroanthramycinabbeymycinanthramycin 11-methyl ethermazethramycin
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Broader (2)

Antibiotics, AntineoplasticBenzodiazepinones
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

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Review
2011
Review
2011
Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).
Pyrrolobenzodiazepines (PBD) are an important class of sequence-selective DNA-interactive agents that bind covalently to guanine… Expand
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2011
2011
A heme peroxidase with a functional role as an L-tyrosine hydroxylase in the biosynthesis of anthramycin.
We report the first characterization and classification of Orf13 (S. refuineus) as a heme-dependent peroxidase catalyzing the… Expand
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Highly Cited
2009
Highly Cited
2009
Biosynthesis of sibiromycin, a potent antitumor antibiotic.
Pyrrolobenzodiazepines, a class of natural products produced by actinomycetes, are sequence selective DNA alkylating compounds… Expand
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2008
2008
Reassembly of anthramycin biosynthetic gene cluster by using recombinogenic cassettes.
The reassembly and heterologous expression of complete gene clusters in shuttle vectors has enabled investigations of several… Expand
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Highly Cited
1996
Highly Cited
1996
DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata.
Ecteinascidin 743 is one of several related marine alkaloids isolated from the Caribbean tunicate Ecteinascidia turbinata. It is… Expand
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Highly Cited
1996
Highly Cited
1996
Recognition of DNA Adducts by Human Nucleotide Excision Repair
The mechanism by which mammalian nucleotide excision repair (NER) detects a wide range of base lesions is poorly understood. Here… Expand
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1994
1994
Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity.
A 2.3-A X-ray crystal structure analysis has been carried out on the antitumor drug anthramycin, covalently bound to a ten base… Expand
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Review
1986
Review
1986
Nonintercalating DNA-binding ligands: specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material.
II. DNA BINDING ANTIBIOTICS 1. Pyrrole-Amidine Antibiotics and Synthetic Analogues (a) Structure and physical properties (b… Expand
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1985
1985
Characteristics of the binding of the anticancer agents mitoxantrone and ametantrone and related structures to deoxyribonucleic acids.
The binding constants for interaction of the anticancer agents mitoxantrone and ametantrone and several congeners with calf… Expand
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1965
1965
Isolation and characterization of anthramycin, a new antitumor antibiotic.
 
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