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Anthramycin

Known as: Anthramycin [Chemical/Ingredient], 2-Propenamide, 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-, (11R-(2(E),11alpha,11abeta))-, Antramycin 
A pyrrolo(1,4)benzodiazepine antineoplastic antibiotic isolated from the bacterium Streptomyces refuineus var. thermotolerans. Anthramycin binds… 
National Institutes of Health

Related topics

Related topics

14 relations

Narrower (5)

1,11a-didehydroanhydroanthramycinabbeymycinanthramycin 11-methyl ethermazethramycin

Broader (2)

Antibiotics, AntineoplasticBenzodiazepinones
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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1985
1985
Bicyclic and tricyclic analogues of anthramycin.
As analogues of pyrrolo[2,1-c][1,4]benzodiazepine antitumor antibiotics, such as anthramycin and tomaymycin, several benzo[1,4… 
1985
1985
Structure of the anthramycin-d(ATGCAT)2 adduct from one- and two-dimensional proton NMR experiments in solution.
One- and two-dimensional 400-MHz proton NMR experiments are used to examine the solution structure of the covalent adduct formed… 
1981
1981
Anthramycin inhibition of restriction endonuclease cleavage and its use as a reversible blocking agent in DNA constructions.
Anthramycin can form a stable complex with DNA which does not dissociate upon repeated ethanol precipitations. The complex forms… 
1981
1981
Anthramycin binding to deoxyribonucleic acid-mitomycin C complexes. Evidence for drug-induced deoxyribonucleic acid conformational change and cooperativity in mitomycin C binding.
Anthramycin and mitomycin C (MC) are two DNA reactive drugs, which bind covalently to GC pairs producing different effects on DNA… 
1980
1980
Mazethramycin, a new member of anthramycin group antibiotics.
Sir: A new antitumor antibiotic named mazethramycin has been isolated from the culture broth of Streptomyces thioluteus ME561-L4… 
1979
1979
In vitro and in vivo stability of anthramycin-DNA conjugate and its potential application as an anthramycin prodrug.
Anthramycin-DNA adducts, produced in vitro by reaction of anthramycin with calf thymus DNA, have been shown to be stable only as… 
1979
1979
Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthetic conversion of tyrosine to the C2- and C3-proline moieties of anthramycin, tomaymycin, and sibiromycin.
This paper descirbes biosynthetic labeling experiments on the conversion of tyrosine to the C2- and C3-proline units of… 
1979
1979
Coenzyme Q10 or alpha-tocopherol reduce the acute toxicity of anthramycin in mice.
Pretreatment for 4 days with 10 mg/kg coenzyme Q10 (CoQ) or 1 day with 85U alpha-tocopherol (Vit E) produced equal reduction in… 
1976
1976
Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic 11-demethyltomaymycin and its biologically inactive metabolite oxotomaymycin by Streptomyces achromogenes.
11-Demethyltomaymycin, an antitumor antibiotic produced by Streptomyces achromogenes, and its biologically inactive metabolite… 
1975
1975
Biosynthesis of anthramycin. Determination of the labeling pattern by the use of radioactive and stable isotope techniques.