FAQ

Anthramycin

Known as: Anthramycin [Chemical/Ingredient], 2-Propenamide, 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-, (11R-(2(E),11alpha,11abeta))-, Antramycin 
A pyrrolo(1,4)benzodiazepine antineoplastic antibiotic isolated from the bacterium Streptomyces refuineus var. thermotolerans. Anthramycin binds… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1965-2017
0246819652017

Related topics

Related topics

14 relations

Narrower (5)

1,11a-didehydroanhydroanthramycinabbeymycinanthramycin 11-methyl ethermazethramycin
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Broader (2)

Antibiotics, AntineoplasticBenzodiazepinones
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Anthramycin
In Blood
chemical synthesis
Antibiotics, Antineoplastic
standards characteristics
1,11a-didehydroanhydroanthramycin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Reassembly of anthramycin biosynthetic gene cluster by using recombinogenic cassettes.
The reassembly and heterologous expression of complete gene clusters in shuttle vectors has enabled investigations of several… (More)
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2006
2006
Anthramycin-DNA binding explored by molecular simulations.
The anticancer drug anthramycin inhibits replication and transcription processes by covalently binding to DNA. Here, we use… (More)
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1997
1997
Inhibition of bacteriophage T7 RNA polymerase in vitro transcription by DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines.
The interactions of several pyrrolo[2, 1-c][1,4]benzodiazepine (PBD) antitumor antibiotics with linearized plasmid pGEM-2-N-ras… (More)
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Highly Cited
1996
Highly Cited
1996
DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata.
Ecteinascidin 743 is one of several related marine alkaloids isolated from the Caribbean tunicate Ecteinascidia turbinata. It is… (More)
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1994
1994
Cellular pharmacology of novel C8-linked anthramycin-based sequence-selective DNA minor groove cross-linking agents.
The cellular pharmacology of a series of C8-linked pyrrolobenzodiazepine dimers with polymethylene linkers of n = 3-6 (compounds… (More)
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1988
1988
Recognition of the DNA helix stabilizing anthramycin-N2 guanine adduct by UVRABC nuclease.
The binding of the anti-tumor antibiotic anthramycin to a defined linear DNA fragment was investigated using both exonuclease III… (More)
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1986
1986
Molecular mechanics simulations on covalent complexes between anthramycin and B DNA.
We present molecular mechanics simulation of the covalent interactions of the potent antitumor antibiotic belonging to the… (More)
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1979
1979
Proposed structure of the anthramycin–DNA adduct
Anthramycin, an antitumour antibiotic produced by Streptomyces refuineus1, belongs to the pyrrolo(1,4)benzodiazepine antibiotic… (More)
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Highly Cited
1978
Highly Cited
1978
In vivo characteristics of resistance and cross-resistance of an adriamycin-resistant subline of P388 leukemia.
A subline of P388 leukemia resistant to adriamycin (P388/ADR) was developed by exposure to the drug in vivo. Resistance to… (More)
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1971
1971
Chemosterilant action of anthramycin: a proposed mechanism.
The activity of anthramycin and structurally related analogs as chemosterilants of the housefly, Musca domestica L., correlates… (More)
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