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Anthramycin

Known as: Anthramycin [Chemical/Ingredient], 2-Propenamide, 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-, (11R-(2(E),11alpha,11abeta))-, Antramycin 
A pyrrolo(1,4)benzodiazepine antineoplastic antibiotic isolated from the bacterium Streptomyces refuineus var. thermotolerans. Anthramycin binds… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Abstract The pyrrolo[2,1‐c][1,4]benzodiazepines (PBDs) are a family of sequence‐selective DNA minor‐groove binding agents that… Expand
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Review
2011
Review
2011
Pyrrolobenzodiazepines (PBD) are an important class of sequence-selective DNA-interactive agents that bind covalently to guanine… Expand
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Highly Cited
2009
Highly Cited
2009
ABSTRACT Pyrrolobenzodiazepines, a class of natural products produced by actinomycetes, are sequence selective DNA alkylating… Expand
Review
2004
Review
2004
DNA minor groove binders constitute an important class of derivatives in anticancer therapy. Some of these compounds form… Expand
Highly Cited
1996
Highly Cited
1996
Ecteinascidin 743 is one of several related marine alkaloids isolated from the Caribbean tunicate Ecteinascidia turbinata. It is… Expand
Highly Cited
1994
Highly Cited
1994
A 2.3-A X-ray crystal structure analysis has been carried out on the antitumor drug anthramycin, covalently bound to a ten base… Expand
Review
1986
Review
1986
II. DNA BINDING ANTIBIOTICS 1. Pyrrole-Amidine Antibiotics and Synthetic Analogues (a) Structure and physical properties (b… Expand
Highly Cited
1979
Highly Cited
1979
Anthramycin, an antitumour antibiotic produced by Streptomyces refuineus1, belongs to the pyrrolo(1,4)benzodiazepine antibiotic… Expand
Review
1977
Review
1977
  • L. Hurley
  • The Journal of antibiotics
  • 1977
  • Corpus ID: 40236845
Anthramycin, sibiromycin and tomaymycin are structurally related antibiotics produced by various actinomycetes. Anthramycin was… Expand
Highly Cited
1965
Highly Cited
1965