Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic 11-demethyltomaymycin and its biologically inactive metabolite oxotomaymycin by Streptomyces achromogenes.

@article{Hurley1976Pyrrolo14benzodiazepineAB,
  title={Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic 11-demethyltomaymycin and its biologically inactive metabolite oxotomaymycin by Streptomyces achromogenes.},
  author={L. Hurley and C. Gairola and N. V. Das},
  journal={Biochemistry},
  year={1976},
  volume={15 17},
  pages={
          3760-9
        }
}
  • L. Hurley, C. Gairola, N. V. Das
  • Published 1976
  • Chemistry, Medicine
  • Biochemistry
  • 11-Demethyltomaymycin, an antitumor antibiotic produced by Streptomyces achromogenes, and its biologically inactive metabolite oxotomaymycin are biosynthesized from L-tyrosine, DL-tryptophan, and L-methionine. The anthranilate part of 11-demethyltomaymycin is derived from tryptophan probably via the kynurenine pathway. The predominant loss of tritium from DL-[5-3H]tryptophan, during its conversion to 11-demethyltomaymycin and oxotomaymycin is interpreted to mean by NIH shift rules, that the… CONTINUE READING
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