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Amanitins

Known as: Amanitins [Chemical/Ingredient], amanitin, amanitine 
Cyclic peptides extracted from carpophores of various mushroom species. They are potent inhibitors of RNA polymerases in most eukaryotic species… 
National Institutes of Health

Related topics

Related topics

23 relations

Narrower (11)

2-methyl-demethyl gamma-amanitin6'-O-methyl alpha-amanitinMuscarinealpha-amanitinylazobenzoylglycylglycine

Broader (4)

Enzyme InhibitorsMycotoxinsNucleic Acid Synthesis InhibitorsPoisons
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

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1985
1985
The primase activity of DNA polymerase alpha from calf thymus.
The nearly homogeneous 9 S DNA polymerase alpha from calf thymus contains a primase activity that allows priming of DNA synthesis… 
1982
1982
Specific stimulation of alpha-amanitin-sensitive RNA synthesis in isolated HeLa nuclei by methyl mercury.
Methyl mercury has previously been shown to inhibit DNA and RNA synthesis in intact HeLa cells (Gruenwedel, D. W., and Cruikshank… 
1980
1980
Synthesis of a posterior indicator protein in normal embryos and double abdomens of Smittia sp. (Chironomidae, Diptera).
In embryos of the chironomid midge Smittia, synthesis of a posterior indicator protein designated PI1 (Mr approximately 50,000… 
Highly Cited
1977
Highly Cited
1977
Mechanism of aflatoxin B1 inhibition of rat hepatic nuclear RNA synthesis.
This paper reports the evidence for the existence of multiple sites of action of aflatoxin B1 in relation to its inhibition of… 
1977
1977
The crystal structure of the mushroom toxin beta-amanitin.
The crystal structure of the amatoxin ..beta..-amanitin, isolated and purified from American Amanita phalloides, was determined… 
Highly Cited
1976
Highly Cited
1976
Euglena gracilis DNA dependent RNA polymerase II: a zinc metalloenzyme.
Zinc is essential for cellular proliferation. Zinc deficiency of Euglena gracilis results in arrest of cell division and deranges… 
Highly Cited
1976
Highly Cited
1976
HeLa cell deoxyribonucleic acid dependent RNA polymerases: function and properties of the class III enzymes.
The class III DNA dependent RNA polymerases (nucleoside triphosphate:RNA nucleotidyltransferase EC 2.7.7.6 from HeLa cells have… 
1975
1975
Quantitation of amanitins in Amanita verna with calf thymus RNA polymerase B.
A procedure utilizing the specific inhibition of calf thymus DNA-directed RNA polymerase B has been applied to the quantitation… 
Highly Cited
1972
Highly Cited
1972
State of Adenovirus 2 Deoxyribonucleic Acid in the Nucleus and Its Mode of Transcription: Studies with Isolated Viral Deoxyribonucleic Acid-Protein Complexes and Isolated Nuclei
Newly replicated adenovirus 2 deoxyribonucleic acid (DNA) can be isolated from the nucleus of HeLa cells by a gentle lysis… 
Highly Cited
1971
Highly Cited
1971
RNA polymerases of maize: nuclear RNA polymerases.
Two DNA-dependent RNA polymerases of nuclear origin have been purified from leaves of Zea mays. The two enzymes can be separated…