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Alzheimer's Disease Pathway KEGG

Known as: Alzheimer's Disease 
Alzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile… 
National Institutes of Health

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50 relations
ADAM17 protein, humanADAM17 wt AlleleAPP wt AlleleATP Synthase Subunit Epsilon, Mitochondrial

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains.
Accumulation of dysfunctional mitochondria is one of the hallmarks in Alzheimer's disease (AD). Mitophagy, a selective autophagy… 
Highly Cited
2010
Highly Cited
2010
The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease
Highly Cited
2007
Highly Cited
2007
SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Perivascular Drainage of Amyloid‐β Peptides from the Brain and Its Failure in Cerebral Amyloid Angiopathy and Alzheimer's Disease
Alzheimer's disease is the commonest dementia. One major characteristic of its pathology is accumulation of amyloid‐β (Aβ) as… 
Highly Cited
2007
Highly Cited
2007
Neuroprotective Effects of Regulators of the Glycogen Synthase Kinase-3β Signaling Pathway in a Transgenic Model of Alzheimer's Disease Are Associated with Reduced Amyloid Precursor Protein…
The glycogen synthase kinase-3β (GSK3β) pathway plays an important role in mediating neuronal fate and synaptic plasticity. In… 
Highly Cited
2006
Highly Cited
2006
Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease
Dysfunction of cholinergic basal forebrain (CBF) neurons of the nucleus basalis (NB) is a cardinal feature of Alzheimer's disease… 
Highly Cited
1999
Highly Cited
1999
Alternative, Non-secretase Processing of Alzheimer’s β-Amyloid Precursor Protein during Apoptosis by Caspase-6 and -8*
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. Although the pathogenesis of AD is unknown, it is widely… 
Highly Cited
1999
Highly Cited
1999
Caspase-6 Role in Apoptosis of Human Neurons, Amyloidogenesis, and Alzheimer’s Disease*
Neuronal cell death, neurofibrillary tangles, and amyloid β peptide (Aβ) deposition depict Alzheimer’s disease (AD) pathology… 
Highly Cited
1999
Highly Cited
1999
β‐Amyloid fragment 25–35 selectively decreases complex IV activity in isolated mitochondria
Highly Cited
1989
Highly Cited
1989
Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease
ALZHEIMER'S disease is the most common cause of progressive intellectual failure in aged humans. The filamentous brain lesions… 
Highly Cited
1989
Highly Cited
1989
A4 Protein in Alzheimer's Disease: Primary and Secondary Cellular Events in Extracellular Amyloid Deposition
This study was designed to investigate the role of serum proteins, microglia, glial fibrillary acidic protein (GFAP) positive… 
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