Aldehyde dehydrogenase (NAD+)

Known as: Dehydrogenase, Aldehyde, Aldehyde NAD Oxidoreductase, D Glucuronolactone Dehydrogenase 
An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.
National Institutes of Health

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ALDH1A1 protein, humanAldehyde Dehydrogenase MitochondrialAldehyde Dehydrogenase X, MitochondrialGbsA protein, Bacillus subtilis
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Aldehyde dehydrogenase (NAD(P)+)In BloodProcess of secretionaldehyde dehydrogenase (NAD+) activity
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Broader (1)

aldehyde dehydrogenases

Papers overview

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Highly Cited
2008
Highly Cited
2008
Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.
There is substantial interest in the development of drugs that limit the extent of ischemia-induced cardiac damage caused by… (More)
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Review
2007
Review
2007
The Genetics of Alcohol Metabolism: Role of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Variants
The primary enzymes involved in alcohol metabolism are alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Both… (More)
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Highly Cited
2005
Highly Cited
2005
Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family
The aldehyde dehydrogenase (ALDH) gene superfamily encodes enzymes that are critical for certain life processes and… (More)
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Highly Cited
2004
Highly Cited
2004
Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance.
Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin… (More)
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Highly Cited
2003
Highly Cited
2003
Aldehyde dehydrogenase gene superfamily: the 2002 update.
The aldehyde dehydrogenase (ALDH) superfamily represents a divergently related group of enzymes that metabolize a wide variety of… (More)
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Highly Cited
2002
Highly Cited
2002
Inhibition effects of furfural on alcohol dehydrogenase, aldehyde dehydrogenase and pyruvate dehydrogenase.
The kinetics of furfural inhibition of the enzymes alcohol dehydrogenase (ADH; EC 1.1.1.1), aldehyde dehydrogenase (AlDH; EC 1.2… (More)
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Highly Cited
2001
Highly Cited
2001
Mitochondrial aldehyde dehydrogenase activity is required for male fertility in maize.
Some plant cytoplasms express novel mitochondrial genes that cause male sterility. Nuclear genes that disrupt the accumulation of… (More)
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Highly Cited
1989
Highly Cited
1989
Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.
Many Orientals lack the mitochondrial aldehyde dehydrogenase (ALDH2) activity responsible for the oxidation of acetaldehyde… (More)
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Highly Cited
1984
Highly Cited
1984
Role of aldehyde dehydrogenase in cyclophosphamide-resistant L1210 leukemia.
A cyclophosphamide-resistant L1210 cell line has been shown to have unusually high aldehyde dehydrogenase activity. The… (More)
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Highly Cited
1984
Highly Cited
1984
Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals.
Usual human livers contain two major aldehyde dehydrogenase [(ALDH) aldehyde:NAD+ oxidoreductase] isozymes--i.e., a cytosolic… (More)
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